(Q21119108)

1 reference

27 February 2018

Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

DNA-binding transcription factor activity

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

E-box binding

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

protein C-terminus binding

1 reference

27 February 2018

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

protein binding

7 references

27 February 2018

The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

A human MAP kinase interactome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

DNA-binding transcription factor activity, RNA polymerase II-specific

A census of human transcription factors: function, expression and evolution

2 references

27 February 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

NAS

27 February 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

ISM

cell component

cytoplasm

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

TAS

SREBP-SCAP-Insig complex

2 references

27 February 2018

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

Golgi apparatus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

3 references

27 February 2018

27 February 2018

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

ER to Golgi transport vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

7 references

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

intracellular membrane-bounded organelle

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

steroid metabolic process

biological process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

positive regulation of protein targeting to mitochondrion

1 reference

27 February 2018

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

lipid metabolism

TAS

positive regulation of cholesterol storage

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

cellular response to laminar fluid shear stress

NAS

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

cellular response to starvation

NAS

1 reference

27 February 2018

Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

cholesterol metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

negative regulation of transcription by RNA polymerase II

2 references

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

regulation of autophagy of mitochondrion

1 reference

27 February 2018

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

negative regulation of cholesterol efflux

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

positive regulation of transcription by RNA polymerase II

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

27 February 2018

Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

regulation of cholesterol biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

1 reference

27 February 2018

cellular response to low-density lipoprotein particle stimulus

TAS

IEP

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772