(Q24650641)

English

Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors

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scholarly article

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Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors (English)

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author name string

P Malherbe

1

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R Masciadri

2

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R D Norcross

3

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F Knoflach

4

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C Kratzeisen

5

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M-T Zenner

6

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Y Kolb

7

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A Marcuz

8

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J Huwyler

9

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T Nakagawa

10

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R H P Porter

11

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A W Thomas

12

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J G Wettstein

13

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A J Sleight

14

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W Spooren

15

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E P Prinssen

16

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publication date

June 2008

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British Journal of Pharmacology

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154

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4

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797-811

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Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

7 April 2017

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

7 April 2017

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

7 April 2017

https://api.crossref.org/works/10.1038%2FBJP.2008.135

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of GABAB receptor ligands in animal tests of depression and anxiety.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

Differential compartmentalization and distinct functions of GABAB receptor variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: a review of pharmacological and genetic studies in the mouse

1 reference

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28 September 2017

Differential modulation by the GABAB receptor allosteric potentiator 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

GABAergic hypotheses of anxiety and depression: focus on GABA-B receptors

1 reference

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28 September 2017

GABAB receptor: a site of therapeutic benefit

1 reference

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28 September 2017

Allosteric functioning of dimeric class C G-protein-coupled receptors.

1 reference

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28 September 2017

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

1 reference

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28 September 2017

In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

Molecular structure and physiological functions of GABA(B) receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain

1 reference

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28 September 2017

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

GABA(B) receptors as potential therapeutic targets

1 reference

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28 September 2017

Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

1 reference

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28 September 2017

No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 September 2017

3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

1 reference

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28 September 2017

Role of gamma-aminobutyric acid in antipanic drug efficacy

1 reference

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28 September 2017

GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

30 May 2018

Effects of GABAB receptor ligands in rodent tests of anxiety-like behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 November 2018

The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons

1 reference

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28 November 2018

The positive allosteric modulator GS39783 enhances GABA(B) receptor-mediated inhibition of cyclic AMP formation in rat striatum in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 November 2018

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2439845

28 November 2018

Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits.

1 reference

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28 November 2018

Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains

1 reference

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28 November 2018

Peripheral GABAB agonists stimulate gastric acid secretion in mice.

1 reference

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28 November 2018

Baclofen treatment for chronic posttraumatic stress disorder

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28 November 2018

Effects of gamma-aminobutyrate B receptor modulation on normal micturition and oxyhemoglobin induced detrusor overactivity in female rats

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28 November 2018

The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor

1 reference

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28 November 2018

Baclofen-mediated gastro-oesophageal acid reflux control in patients with established reflux disease

1 reference

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28 November 2018

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

1 reference

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28 November 2018

Allosteric activation of the Ca2+ receptor expressed in Xenopus laevis oocytes by NPS 467 or NPS 568.

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28 November 2018

The expression of GABA(B1) and GABA(B2) receptor subunits in the cNS differs from that in peripheral tissues

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Mapping the agonist-binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536733

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJP.2008.135

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