During a 4-year period 59 patients were treated with an elemental diet (Vivasorb®) for 1–6 weeks.... more During a 4-year period 59 patients were treated with an elemental diet (Vivasorb®) for 1–6 weeks. The great majority (41 patients) were suffering from chronic inflammatory bowel disease. The indication for treatment was insufficient remission on prednisone 10–60 mg daily for 1–4 weeks or no remission after a high dose of prednisone (60–120 mg) for 1–4 weeks. Remission was obtained in 14 patients on elemental diet and a constant or decreasing dose of prednisone and in another 6 on elemental diet and a high dose of prednisone. Thus, a total of 20 patients (50%) remitted. This includes 12 out of 24 with ulcerative colitis, and 8 out of 17 with Crohn’s disease. It was not possible to demonstrate significant differences between the groups having moderate and severe disease activity, or between those with topographically restricted and with extensive lesions. The remission was long. During this treatment of patients with chronic inflammatory bowel disease there occurred a significant redu...
After the establishment of a centralised unit for the surgical treatment of breast cancer in the ... more After the establishment of a centralised unit for the surgical treatment of breast cancer in the county of Copenhagen, Denmark, a number of parameters concerning the quality of patients' in-hospital stay were established. A survey of patients' experiences was done via a questionnaire in which they described their satisfaction level. Two questionnaires including 43 questions were sent to 400 women recently operated on for primary breast cancer. They were returned by 269 patients, who were included in the study. The patients indicated a high degree of satisfaction with the general aspects of their hospital stay, but problems and possible areas of future improvement were also identified. Even with a malignant diagnosis and a short hospital stay, patients may regard the treatment course positively if and when the course is firmly anchored in well-established quality goals.
The role of antiestrogen treatment of postmenopausal breast cancer patients with high risk of rec... more The role of antiestrogen treatment of postmenopausal breast cancer patients with high risk of recurrent disease is evaluated in a nationwide, prospective trial conducted by the Danish Breast Cancer Cooperative Group (DBCG). After total mastectomy and postoperative radiotherapy (RT), 840 patients were randomized to treatment with tamoxifen (RT + TAM) for one year, and 824 were randomized to no further therapy (RT). The recurrenceree survival (RFS) after ten years of lifeable analysis is 31% in the RT + TAM treated group, and 28% in the RT group (p = 0.01). Survival is 38% and 34% in the two treatment groups, respectively (p = 0.04). The data were further analyzed with respect to prognostic factors such as age, number of positive nodes, tumour size, and degree of anaplasia. Survival is prolonged in nearly all subgroups of patients treated with RT + TAM. However, the prolongation is only significant in patients with four or more positive nodes, with tumours of less than 5 centimeters o...
Journal of the National Cancer Institute. Monographs, 1992
The Danish Breast Cancer Cooperative Group (DBCG) conducted a randomized trial comparing breast c... more The Danish Breast Cancer Cooperative Group (DBCG) conducted a randomized trial comparing breast conservation with mastectomy in patients with invasive mammary carcinoma. From January 1983 to March 1989, the trial accrued a total of 1153 women. Of this number, 905 patients (79%) were randomly assigned to one of the two treatment options, whereas 248 patients (21%) did not accept randomization. Of the randomly assigned patients, 90% received the surgical option to which they had been originally assigned. In the breast conservation arm the tumor was excised with the intention of obtaining free margins determined at gross examination, and radiotherapy was subsequently administered to residual breast tissue. The axilla was dissected in all instances. Patient and tumor characteristics were similar in the two randomization arms. The median follow-up time was 40 months. At 6 years of life-table analysis the probability of recurrence-free survival was 70% in the breast conservation arm again...
Journal of the National Cancer Institute. Monographs, 1992
Classical prognostic factors were analyzed in patients with low-risk primary breast cancer, defin... more Classical prognostic factors were analyzed in patients with low-risk primary breast cancer, defined as absence of tumor-positive axillary lymph nodes, tumor size less than or equal to 5 cm in diameter, and no invasion into skin or deep fascia. The primary surgical treatment was total mastectomy and lower axillary dissection. None of the patients received adjuvant therapy. Between 1977 and 1990, 7315 patients entered the study, and at the time of this analysis (January 1, 1990), the median follow-up time is 5 years. In univariate analyses, the following variables were significantly related to recurrence-free survival: age in premenopausal patients; tumor size; number of negative nodes removed; histological grade; and in premenopausal patients, estrogen receptor and progesterone (PgR) status. In multivariate analyses, age in premenopausal patients was the most important factor, followed by tumor size and histological grade, whereas PgR status in premenopausal patients was just of bord...
International Journal of Bio-Medical Computing, 1990
Application of Stewart-Hamilton's formula to the activity-time curve recorded over a left... more Application of Stewart-Hamilton's formula to the activity-time curve recorded over a left ventricular region of interest following an intravenous bolus injection of a radioactive indicator in gamma camera hepatography has resulted in a new method for determination of the clearance rate constant of the indicator (i.e. the ratio of the clearance to the plasma volume). In a group of 19 normal subjects the clearance rate constant was 0.116 +/- 0.036 min-1 (means +/- 1 S.D.) with 99mTc-diethyl-IDA (SOLCO HIDA) and 0.184 +/- 0.037 min-1 (means +/- 1 S.D.) with 99mTc-diethyl-iodo-IDA (SOLCO IODIDA) in 15 normal subjects. The clearance rate constant is assumed to represent mainly hepatic clearance of the radioactive indicator and to a much smaller extent renal clearance. The literature shows diverging results as to the clearance of 99mTc-diethyl-IDA and the reasons for this are discussed. The correlations between the clearance rate constant of 99mTc-diethyl-IDA and a number of laboratory variables with relation to liver function were moderate to non-existent in a group of 16 subjects with abnormal values of at least one of these variables. The rate constant for clearance as described in the paper represents a non-invasive method for rapid evaluation of the uptake capacity of the liver and, in particular, with regard to the polygonal cells of the liver parenchyma when IDA derivatives are employed. The clinical usefulness of the clearance rate constant is probably superior to the group of routine laboratory variables which also describe other functions than liver uptake.
During a 4-year period 59 patients were treated with an elemental diet (Vivasorb®) for 1–6 weeks.... more During a 4-year period 59 patients were treated with an elemental diet (Vivasorb®) for 1–6 weeks. The great majority (41 patients) were suffering from chronic inflammatory bowel disease. The indication for treatment was insufficient remission on prednisone 10–60 mg daily for 1–4 weeks or no remission after a high dose of prednisone (60–120 mg) for 1–4 weeks. Remission was obtained in 14 patients on elemental diet and a constant or decreasing dose of prednisone and in another 6 on elemental diet and a high dose of prednisone. Thus, a total of 20 patients (50%) remitted. This includes 12 out of 24 with ulcerative colitis, and 8 out of 17 with Crohn’s disease. It was not possible to demonstrate significant differences between the groups having moderate and severe disease activity, or between those with topographically restricted and with extensive lesions. The remission was long. During this treatment of patients with chronic inflammatory bowel disease there occurred a significant redu...
After the establishment of a centralised unit for the surgical treatment of breast cancer in the ... more After the establishment of a centralised unit for the surgical treatment of breast cancer in the county of Copenhagen, Denmark, a number of parameters concerning the quality of patients' in-hospital stay were established. A survey of patients' experiences was done via a questionnaire in which they described their satisfaction level. Two questionnaires including 43 questions were sent to 400 women recently operated on for primary breast cancer. They were returned by 269 patients, who were included in the study. The patients indicated a high degree of satisfaction with the general aspects of their hospital stay, but problems and possible areas of future improvement were also identified. Even with a malignant diagnosis and a short hospital stay, patients may regard the treatment course positively if and when the course is firmly anchored in well-established quality goals.
The role of antiestrogen treatment of postmenopausal breast cancer patients with high risk of rec... more The role of antiestrogen treatment of postmenopausal breast cancer patients with high risk of recurrent disease is evaluated in a nationwide, prospective trial conducted by the Danish Breast Cancer Cooperative Group (DBCG). After total mastectomy and postoperative radiotherapy (RT), 840 patients were randomized to treatment with tamoxifen (RT + TAM) for one year, and 824 were randomized to no further therapy (RT). The recurrenceree survival (RFS) after ten years of lifeable analysis is 31% in the RT + TAM treated group, and 28% in the RT group (p = 0.01). Survival is 38% and 34% in the two treatment groups, respectively (p = 0.04). The data were further analyzed with respect to prognostic factors such as age, number of positive nodes, tumour size, and degree of anaplasia. Survival is prolonged in nearly all subgroups of patients treated with RT + TAM. However, the prolongation is only significant in patients with four or more positive nodes, with tumours of less than 5 centimeters o...
Journal of the National Cancer Institute. Monographs, 1992
The Danish Breast Cancer Cooperative Group (DBCG) conducted a randomized trial comparing breast c... more The Danish Breast Cancer Cooperative Group (DBCG) conducted a randomized trial comparing breast conservation with mastectomy in patients with invasive mammary carcinoma. From January 1983 to March 1989, the trial accrued a total of 1153 women. Of this number, 905 patients (79%) were randomly assigned to one of the two treatment options, whereas 248 patients (21%) did not accept randomization. Of the randomly assigned patients, 90% received the surgical option to which they had been originally assigned. In the breast conservation arm the tumor was excised with the intention of obtaining free margins determined at gross examination, and radiotherapy was subsequently administered to residual breast tissue. The axilla was dissected in all instances. Patient and tumor characteristics were similar in the two randomization arms. The median follow-up time was 40 months. At 6 years of life-table analysis the probability of recurrence-free survival was 70% in the breast conservation arm again...
Journal of the National Cancer Institute. Monographs, 1992
Classical prognostic factors were analyzed in patients with low-risk primary breast cancer, defin... more Classical prognostic factors were analyzed in patients with low-risk primary breast cancer, defined as absence of tumor-positive axillary lymph nodes, tumor size less than or equal to 5 cm in diameter, and no invasion into skin or deep fascia. The primary surgical treatment was total mastectomy and lower axillary dissection. None of the patients received adjuvant therapy. Between 1977 and 1990, 7315 patients entered the study, and at the time of this analysis (January 1, 1990), the median follow-up time is 5 years. In univariate analyses, the following variables were significantly related to recurrence-free survival: age in premenopausal patients; tumor size; number of negative nodes removed; histological grade; and in premenopausal patients, estrogen receptor and progesterone (PgR) status. In multivariate analyses, age in premenopausal patients was the most important factor, followed by tumor size and histological grade, whereas PgR status in premenopausal patients was just of bord...
International Journal of Bio-Medical Computing, 1990
Application of Stewart-Hamilton's formula to the activity-time curve recorded over a left... more Application of Stewart-Hamilton's formula to the activity-time curve recorded over a left ventricular region of interest following an intravenous bolus injection of a radioactive indicator in gamma camera hepatography has resulted in a new method for determination of the clearance rate constant of the indicator (i.e. the ratio of the clearance to the plasma volume). In a group of 19 normal subjects the clearance rate constant was 0.116 +/- 0.036 min-1 (means +/- 1 S.D.) with 99mTc-diethyl-IDA (SOLCO HIDA) and 0.184 +/- 0.037 min-1 (means +/- 1 S.D.) with 99mTc-diethyl-iodo-IDA (SOLCO IODIDA) in 15 normal subjects. The clearance rate constant is assumed to represent mainly hepatic clearance of the radioactive indicator and to a much smaller extent renal clearance. The literature shows diverging results as to the clearance of 99mTc-diethyl-IDA and the reasons for this are discussed. The correlations between the clearance rate constant of 99mTc-diethyl-IDA and a number of laboratory variables with relation to liver function were moderate to non-existent in a group of 16 subjects with abnormal values of at least one of these variables. The rate constant for clearance as described in the paper represents a non-invasive method for rapid evaluation of the uptake capacity of the liver and, in particular, with regard to the polygonal cells of the liver parenchyma when IDA derivatives are employed. The clinical usefulness of the clearance rate constant is probably superior to the group of routine laboratory variables which also describe other functions than liver uptake.
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