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| Verfasst von: | Moinzadeh, Pia [VerfasserIn]  |
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| | Kuhr, Kathrin [VerfasserIn] |
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| | Siegert, Elise [VerfasserIn] |
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| | Blank, Norbert [VerfasserIn] |
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| | Sunderkoetter, Cord [VerfasserIn] |
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| | Henes, Jörg [VerfasserIn] |
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| | Krusche, Martin [VerfasserIn] |
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| | Schmalzing, Marc [VerfasserIn] |
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| | Worm, Margitta [VerfasserIn] |
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| | Schmeiser, Tim [VerfasserIn] |
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| | Günther, Claudia [VerfasserIn] |
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| | Aberer, Elisabeth [VerfasserIn] |
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| | Susok, Laura [VerfasserIn] |
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| | Riemekasten, Gabriela [VerfasserIn] |
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| | Kreuter, Alexander [VerfasserIn] |
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| | Zeidler, Gabriele [VerfasserIn] |
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| | Juche, Aaron [VerfasserIn] |
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| | Hadjiski, Denitsa [VerfasserIn] |
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| | Müller-Ladner, Ulf [VerfasserIn] |
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| | Gaebelein-Wissing, Noemi [VerfasserIn] |
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| | Distler, Jörg H. W. [VerfasserIn] |
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| | Sárdy, Miklós [VerfasserIn] |
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| | Krieg, Thomas [VerfasserIn] |
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| | Hunzelmann, Nicolas [VerfasserIn] |
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| Titel: | Scleroderma renal crisis |
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| Titelzusatz: | risk factors for an increasingly rare organ complication |
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| Verf.angabe: | Pia Moinzadeh, Kathrin Kuhr, Elise Siegert, Norbert Blank, Cord Sunderkoetter, Jörg Henes, Martin Krusche, Marc Schmalzing, Margitta Worm, Tim Schmeiser, Claudia Günther, Elisabeth Aberer, Laura Susok, Gabriela Riemekasten, Alexander Kreuter, Gabriele Zeidler, Aaron Juche, Denitsa Hadjiski, Ulf Müller-Ladner, Noemi Gaebelein-Wissing, Jörg H. W. Distler, Miklós Sárdy, Thomas Krieg, and Nicolas Hunzelmann |
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| E-Jahr: | 2020 |
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| Jahr: | [2020] |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 23.04.2020 |
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| Titel Quelle: | Enthalten in: The journal of rheumatology |
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| Ort Quelle: | Toronto, Ont., 2001 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 47(2020), 2, Seite 241-248 |
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| ISSN Quelle: | 1499-2752 |
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| Abstract: | Objective. Scleroderma renal crisis (SRC) is a severe life-threatening manifestation in patients with systemic sclerosis (SSc). However, the knowledge about risk factors for SRC is limited. We determined here the frequency of SRC and identified risk factors for the prediction of SRC. - Methods. Based on regular followup data from the German Network for Systemic Scleroderma, we used univariate and multivariate generalized estimating equations to analyze the association between clinical variables, SSc subsets, therapy [i.e., angiotensin-converting enzyme inhibitors (ACEi), corticosteroids], and the occurrence of SRC. - Results. Data of 2873 patients with 10,425 visits were available for analysis with a mean number of registry visits of 3.6 ± 2.8 and a mean time of followup of 3.6 ± 3.8 years. In total, 70 patients developed SRC (70/2873, 2.4%). Of these patients, 57.1% (40/70) were diagnosed with diffuse cutaneous SSc, 31.4% (22/70) with limited cutaneous SSc, and 11.4% (8/70) with SSc-overlap syndromes. Predictive independent factors with the highest probability for SRC were positive anti-RNA polymerase antibodies (RNAP), a history of proteinuria prior to SRC onset, diminished DLCO, and a history of hypertension. Interestingly, positive antitopoisomerase autoantibodies did not predict a higher risk for SRC. Further, patients with SRC were significantly more frequently treated with ACEi and corticosteroids without being independently associated with SRC. - Conclusion. In this cohort, SRC has become a rare complication. By far the highest risk for SRC was associated with the detection of anti-RNAP and proteinuria. |
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| DOI: | doi:10.3899/jrheum.180582 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3899/jrheum.180582 |
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| | Volltext: http://www.jrheum.org/content/47/2/241 |
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| | DOI: https://doi.org/10.3899/jrheum.180582 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | GERMAN NETWORK FOR SYSTEMIC SCLERODERMA |
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| | RENAL CRISIS |
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| | SCLERODERMA |
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| | SCLERODERMA RENAL CRISIS |
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| | SYSTEMIC SCLEROSIS |
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| K10plus-PPN: | 1695803205 |
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| Verknüpfungen: | → Zeitschrift |
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Scleroderma renal crisis / Moinzadeh, Pia [VerfasserIn]; [2020] (Online-Ressource)
