American Journal of Hospice and Palliative Medicine®, 2011
Dear Editor, The recent topical review by Bigal and Lipton [2] raises some important issues conce... more Dear Editor, The recent topical review by Bigal and Lipton [2] raises some important issues concerning the role of opioids in the treatment of migraine. In their discussion, ‘‘Mechanisms of opioid induced chronification of migraine”, there is no mention of opioid glial activation [3,4]. A number of features would also suggest that glial activation is a factor in migraine [1]. Morphine appears to act not only on the classical opioid receptors on neurons, but also on glial receptors. At the same time that morphine is providing pain relief, the glial cells are also making neuroexcitatory mediators. The end additive result is a reduction in pain, however with prolonged opioid use glial activation increases leading to the phenomenon of analgesic tolerance. Opioid-induced glial activation can contribute to the allodynia and hyperalgesia that results from chronic opioid administration. The phenomenon of both neuronal and glial activation is shared with other clinically relevant opioids [3]. The clinical observations discussed by Bigal and Lipton [2] together with glial activation induced by excessive opioid use would suggest that one should be very cautious in using opioids in migraine prophylaxis. 262 Letters to the Editor / PAIN 145 (2009) 259–263
Sleep disturbance is a common complication among patients with sickle cell disease (SCD). The pre... more Sleep disturbance is a common complication among patients with sickle cell disease (SCD). The prevalence of sleep disturbances and their impact on affective status, stress and pain has not been well documented among adult patients with SCD. The findings of this study suggested that sleep disturbances are common and distressing among adults with SCD. This study represents an important step in addressing sleep disturbances in this population and implications for future directions in research are discussed.
The current study tested a non-linear model of religious coping among Black patients with Sickle ... more The current study tested a non-linear model of religious coping among Black patients with Sickle Cell Disease (SCD). We predicted that moderate prayer and church attendance would be associated with less severe affective and sensory ratings of pain, lower levels of psychopathology, and less frequent care utilization. The participants were 67 SCD patients, mean age 36.82 ± 11.47 (range 18–70) of which
The current study tested a non-linear model of religious coping among Black patients with Sickle ... more The current study tested a non-linear model of religious coping among Black patients with Sickle Cell Disease (SCD). We predicted that moderate prayer and church attendance would be associated with less severe affective and sensory ratings of pain, lower levels of psychopathology, and less frequent care utilization. The participants were 67 SCD patients, mean age 36.82 ± 11.47 (range 18–70) of which
Sickle cell disease (SCD) refers to a category of genetic illnesses in which the hemoglobin has a... more Sickle cell disease (SCD) refers to a category of genetic illnesses in which the hemoglobin has an irregular, sickled shape and does not carry oxygen efficiently. Ninety-six African American adults with SCD from the Duke University Medical Center’s Sickle Cell Clinic were administered a standardized questionnaire to evaluate psychosocial and medical information. Region of pain was found to significantly affect the number of times participants were hospitalized in the past year, F (2,
While pain is the hallmark symptom of SCD, respiratory illnesses within this population are commo... more While pain is the hallmark symptom of SCD, respiratory illnesses within this population are common. Respiratory illnesses and their influences on physiological and psychological functioning are not well understood. The purpose of this study was to investigate the effect of dyspnea, a primary respiratory symptom associated with many diseases, on pain and psychological functioning among adult African American patients with SCD. Our results indicated that dyspnea, after controlling for age and gender, did not exert influence on reports of pain
Page 1. of December 8, 2010 This information is current as 1972;108;1312-1318 J Immunol Monaco Ma... more Page 1. of December 8, 2010 This information is current as 1972;108;1312-1318 J Immunol Monaco Mary L. Wood and Anthony P. Martin S. Hirsch, Paul H. Black, in Immunosuppressed Hosts Infections on Oncogenic Virus Effects of Pyran Copolymer References ...
American Journal of Hospice and Palliative Medicine®, 2011
Dear Editor, The recent topical review by Bigal and Lipton [2] raises some important issues conce... more Dear Editor, The recent topical review by Bigal and Lipton [2] raises some important issues concerning the role of opioids in the treatment of migraine. In their discussion, ‘‘Mechanisms of opioid induced chronification of migraine”, there is no mention of opioid glial activation [3,4]. A number of features would also suggest that glial activation is a factor in migraine [1]. Morphine appears to act not only on the classical opioid receptors on neurons, but also on glial receptors. At the same time that morphine is providing pain relief, the glial cells are also making neuroexcitatory mediators. The end additive result is a reduction in pain, however with prolonged opioid use glial activation increases leading to the phenomenon of analgesic tolerance. Opioid-induced glial activation can contribute to the allodynia and hyperalgesia that results from chronic opioid administration. The phenomenon of both neuronal and glial activation is shared with other clinically relevant opioids [3]. The clinical observations discussed by Bigal and Lipton [2] together with glial activation induced by excessive opioid use would suggest that one should be very cautious in using opioids in migraine prophylaxis. 262 Letters to the Editor / PAIN 145 (2009) 259–263
Sleep disturbance is a common complication among patients with sickle cell disease (SCD). The pre... more Sleep disturbance is a common complication among patients with sickle cell disease (SCD). The prevalence of sleep disturbances and their impact on affective status, stress and pain has not been well documented among adult patients with SCD. The findings of this study suggested that sleep disturbances are common and distressing among adults with SCD. This study represents an important step in addressing sleep disturbances in this population and implications for future directions in research are discussed.
The current study tested a non-linear model of religious coping among Black patients with Sickle ... more The current study tested a non-linear model of religious coping among Black patients with Sickle Cell Disease (SCD). We predicted that moderate prayer and church attendance would be associated with less severe affective and sensory ratings of pain, lower levels of psychopathology, and less frequent care utilization. The participants were 67 SCD patients, mean age 36.82 ± 11.47 (range 18–70) of which
The current study tested a non-linear model of religious coping among Black patients with Sickle ... more The current study tested a non-linear model of religious coping among Black patients with Sickle Cell Disease (SCD). We predicted that moderate prayer and church attendance would be associated with less severe affective and sensory ratings of pain, lower levels of psychopathology, and less frequent care utilization. The participants were 67 SCD patients, mean age 36.82 ± 11.47 (range 18–70) of which
Sickle cell disease (SCD) refers to a category of genetic illnesses in which the hemoglobin has a... more Sickle cell disease (SCD) refers to a category of genetic illnesses in which the hemoglobin has an irregular, sickled shape and does not carry oxygen efficiently. Ninety-six African American adults with SCD from the Duke University Medical Center’s Sickle Cell Clinic were administered a standardized questionnaire to evaluate psychosocial and medical information. Region of pain was found to significantly affect the number of times participants were hospitalized in the past year, F (2,
While pain is the hallmark symptom of SCD, respiratory illnesses within this population are commo... more While pain is the hallmark symptom of SCD, respiratory illnesses within this population are common. Respiratory illnesses and their influences on physiological and psychological functioning are not well understood. The purpose of this study was to investigate the effect of dyspnea, a primary respiratory symptom associated with many diseases, on pain and psychological functioning among adult African American patients with SCD. Our results indicated that dyspnea, after controlling for age and gender, did not exert influence on reports of pain
Page 1. of December 8, 2010 This information is current as 1972;108;1312-1318 J Immunol Monaco Ma... more Page 1. of December 8, 2010 This information is current as 1972;108;1312-1318 J Immunol Monaco Mary L. Wood and Anthony P. Martin S. Hirsch, Paul H. Black, in Immunosuppressed Hosts Infections on Oncogenic Virus Effects of Pyran Copolymer References ...
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