Revista Brasileira De Hematologia E Hemoterapia, 2010
This is a literature review about large granular lymphocyte leukemia (LGLL), a rare and misdiagno... more This is a literature review about large granular lymphocyte leukemia (LGLL), a rare and misdiagnosed oncohematological disease, characterized by a clonal expansion of T-cells (T-LGLL) or NK-cells (NK-LGLL) in the bone marrow and/or peripheral blood. The clinical features of LGLL include cytopenias (anemia, neutropenia and thrombocytopenia), lymphocytosis (usually discrete), lymphadenopathy, hepatomegaly, splenomegaly, immune abnormalities and constitutional symptoms (fever, night sweats and weight loss). The diagnosis is based on the confirmation of the clonality of T-cells or NK-cells (polymerase chain reaction and Southern blot are the two methods most commonly used) and typical findings of the immunophenotypic analysis of peripheral blood lymphocytes (flow cytometry analyses for specific surface antigens). In contrast to the chronic and indolent course of T-LGLL, NK-LGLL has an acute presentation and poor clinical outcome. There are different current treatment options, depending on clinical presentation.
... In clinical trials of chronic spasticity, we found that 33% and 50% changes in the Ashworth S... more ... In clinical trials of chronic spasticity, we found that 33% and 50% changes in the Ashworth Scale scores correlate with 1-point ... Scale (MRDSS) Predicts Clinical Progression in Multiple Sclerosis Rohit Bakshi*; Mohit Neema, Brian C Healy, Zsuzsanna Liptak, Rebecca A. Betensky ...
Revista Brasileira De Hematologia E Hemoterapia, 2010
This is a literature review about large granular lymphocyte leukemia (LGLL), a rare and misdiagno... more This is a literature review about large granular lymphocyte leukemia (LGLL), a rare and misdiagnosed oncohematological disease, characterized by a clonal expansion of T-cells (T-LGLL) or NK-cells (NK-LGLL) in the bone marrow and/or peripheral blood. The clinical features of LGLL include cytopenias (anemia, neutropenia and thrombocytopenia), lymphocytosis (usually discrete), lymphadenopathy, hepatomegaly, splenomegaly, immune abnormalities and constitutional symptoms (fever, night sweats and weight loss). The diagnosis is based on the confirmation of the clonality of T-cells or NK-cells (polymerase chain reaction and Southern blot are the two methods most commonly used) and typical findings of the immunophenotypic analysis of peripheral blood lymphocytes (flow cytometry analyses for specific surface antigens). In contrast to the chronic and indolent course of T-LGLL, NK-LGLL has an acute presentation and poor clinical outcome. There are different current treatment options, depending on clinical presentation.
... In clinical trials of chronic spasticity, we found that 33% and 50% changes in the Ashworth S... more ... In clinical trials of chronic spasticity, we found that 33% and 50% changes in the Ashworth Scale scores correlate with 1-point ... Scale (MRDSS) Predicts Clinical Progression in Multiple Sclerosis Rohit Bakshi*; Mohit Neema, Brian C Healy, Zsuzsanna Liptak, Rebecca A. Betensky ...
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