Multiple sclerose
| Multiple sclerose |
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| instantia de: designated intractable/rare disease[*], classe de maladias[*], symptom or sign[*] |
| subclasse de: maladia demyelinisante[*], demyelinating disease of central nervous system[*], autoimmune disease of central nervous system[*], maladia |
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| Commons: Multiple sclerosis |
Multiple sclerose (MS) es un autoimmun maladia neurodegenerative affectante le copertura del cellulas nervose del cerebro e medulla spinal.
Signos e symptomas
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Causas
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MS non es considerate como un maladia hereditari ma plure genetic variationes augmenta le risco de disveloppar lo.[1]
Genes ligate con MS include human leukocyte antigen (HLA) systema — un gruppo de genes sul chromosoma 6 qui servi como major histocompatibilitate complexo (MHC).[2] Le cambios in HLA region pote alsi esser implicate in the disveloppamento de altere autoimmun disordines, como diabete de typo I o lupo erythematose systemic.[3] Le association le plus consistente concerna allelos DR15 e DQ6 del MHC.[2] Foras HLA locos, al minus 200 variantes pote augmentar un pauc le probabilitate de MS.[4]
Un genetic variante locate inter genes DYSF e ZNF638 permitterea un progression plus rapide del maladia.[5][6]
Referentias
[modificar fonte]- ↑ "Genetics of multiple sclerosis" (February 2004). The Lancet. Neurology 3 (2): 104–10. doi:. PMID 14747002.
- ↑ 2,0 2,1 "Multiple sclerosis" (October 2008). Lancet 372 (9648): 1502–1517. doi:. PMID 18970977.
- ↑ "Revealing the genetic basis of multiple sclerosis: are we there yet?" (June 2011). Current Opinion in Genetics & Development 21 (3): 317–24. doi:. PMID 21247752.
- ↑ International Multiple Sclerosis Genetics Consortium (2019). "Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.". Science 365 (6460). doi:. PMID 31604244.
- ↑ https://neurosciencenews.com/genetics-progressive-ms-23546/
- ↑ doi:10.1038/s41586-023-06250-x