Table of Contents

Commentary

Select this article
An emerging toolkit for targeted cancer therapies
- Gordon B. Mills
Genome Res. February 2012 22: 177-182; doi:10.1101/gr.136044.111

Perspectives

Select this article
Translational genomics: The challenge of developing cancer biomarkers
- James D. Brooks
Genome Res. February 2012 22: 183-187; doi:10.1101/gr.124347.111
Select this article
Translating cancer ‘omics’ to improved outcomes
- Emily A. Vucic,
- Kelsie L. Thu,
- Keith Robison,
- Leszek A. Rybaczyk,
- Raj Chari,
- Carlos E. Alvarez,
- and Wan L. Lam
Genome Res. February 2012 22: 188-195; doi:10.1101/gr.124354.111

Methods

Select this article
Single-step capture and sequencing of natural DNA for detection of BRCA1 mutations
- John F. Thompson,
- Jeffrey G. Reifenberger,
- Eldar Giladi,
- Kristen Kerouac,
- Jaime Gill,
- Erik Hansen,
- Avak Kahvejian,
- Philipp Kapranov,
- Travis Knope,
- Doron Lipson,
- Kathleen E. Steinmann,
- and Patrice M. Milos
Genome Res. February 2012 22: 340-345; Published in Advance July 15, 2011, doi:10.1101/gr.122192.111
Select this article
Estimation of rearrangement phylogeny for cancer genomes
- Chris D. Greenman,
- Erin D. Pleasance,
- Scott Newman,
- Fengtang Yang,
- Beiyuan Fu,
- Serena Nik-Zainal,
- David Jones,
- King Wai Lau,
- Nigel Carter,
- Paul A.W. Edwards,
- P. Andrew Futreal,
- Michael R. Stratton,
- and Peter J. Campbell
Genome Res. February 2012 22: 346-361; Published in Advance October 12, 2011, doi:10.1101/gr.118414.110
OPEN ACCESS ARTICLE
Select this article
Calling amplified haplotypes in next generation tumor sequence data
- Ninad Dewal,
- Yang Hu,
- Matthew L. Freedman,
- Thomas LaFramboise,
- and Itsik Pe'er
Genome Res. February 2012 22: 362-374; Published in Advance November 16, 2011, doi:10.1101/gr.122564.111
Select this article
De novo discovery of mutated driver pathways in cancer
- Fabio Vandin,
- Eli Upfal,
- and Benjamin J. Raphael
Genome Res. February 2012 22: 375-385; Published in Advance June 7, 2011, doi:10.1101/gr.120477.111
Select this article
Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets
- Qing Xiong,
- Nicola Ancona,
- Elizabeth R. Hauser,
- Sayan Mukherjee,
- and Terrence S. Furey
Genome Res. February 2012 22: 386-397; Published in Advance September 22, 2011, doi:10.1101/gr.124370.111
OPEN ACCESS ARTICLE
Select this article
Mutual exclusivity analysis identifies oncogenic network modules
- Giovanni Ciriello,
- Ethan Cerami,
- Chris Sander,
- and Nikolaus Schultz
Genome Res. February 2012 22: 398-406; Published in Advance September 9, 2011, doi:10.1101/gr.125567.111
OPEN ACCESS ARTICLE

Resource

Select this article
A DNA methylation fingerprint of 1628 human samples
- Agustin F. Fernandez,
- Yassen Assenov,
- Jose Ignacio Martin-Subero,
- Balazs Balint,
- Reiner Siebert,
- Hiroaki Taniguchi,
- Hiroyuki Yamamoto,
- Manuel Hidalgo,
- Aik-Choon Tan,
- Oliver Galm,
- Isidre Ferrer,
- Montse Sanchez-Cespedes,
- Alberto Villanueva,
- Javier Carmona,
- Jose V. Sanchez-Mut,
- Maria Berdasco,
- Victor Moreno,
- Gabriel Capella,
- David Monk,
- Esteban Ballestar,
- Santiago Ropero,
- Ramon Martinez,
- Marta Sanchez-Carbayo,
- Felipe Prosper,
- Xabier Agirre,
- Mario F. Fraga,
- Osvaldo Graña,
- Luis Perez-Jurado,
- Jaume Mora,
- Susana Puig,
- Jaime Prat,
- Lina Badimon,
- Annibale A. Puca,
- Stephen J. Meltzer,
- Thomas Lengauer,
- John Bridgewater,
- Christoph Bock,
- and Manel Esteller
Genome Res. February 2012 22: 407-419; Published in Advance May 25, 2011, doi:10.1101/gr.119867.110
OPEN ACCESS ARTICLE

Commentary

An emerging toolkit for targeted cancer therapies

Perspectives

Translational genomics: The challenge of developing cancer biomarkers

Translating cancer ‘omics’ to improved outcomes

Research

Whole genome sequencing of matched primary and metastatic acral melanomas

Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency

Genomic analysis of circulating cell-free DNA infers breast cancer dormancy

Assessment of palindromes as platforms for DNA amplification in breast cancer

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription

Genome-scale analysis of aberrant DNA methylation in colorectal cancer

Unique DNA methylome profiles in CpG island methylator phenotype colon cancers

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer

Cooperation between Polycomb and androgen receptor during oncogenic transformation

Genetic variation in radiation-induced cell death

Methods

Single-step capture and sequencing of natural DNA for detection of BRCA1 mutations

Estimation of rearrangement phylogeny for cancer genomes

Calling amplified haplotypes in next generation tumor sequence data

De novo discovery of mutated driver pathways in cancer

Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets

Mutual exclusivity analysis identifies oncogenic network modules

Resource

A DNA methylation fingerprint of 1628 human samples

This Issue

Preprint Server

Current Issue

From the Cover