Arduino Not uploading

Arduino: 1.8.13 Hourly Build 2020/04/27 05:33 (Windows 10), Board: "Arduino Uno"

Sketch uses 15006 bytes (46%) of program storage space. Maximum is 32256 bytes.
Global variables use 414 bytes (20%) of dynamic memory, leaving 1634 bytes for local variables. Maximum is 2048 bytes.
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0xef
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 2 of 10: not in sync: resp=0xef
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 3 of 10: not in sync: resp=0xef
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 4 of 10: not in sync: resp=0xef
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 5 of 10: not in sync: resp=0xef
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 6 of 10: not in sync: resp=0xef
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 7 of 10: not in sync: resp=0xef
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 8 of 10: not in sync: resp=0xef
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 9 of 10: not in sync: resp=0xef
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0xef
Problem uploading to board. See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.

This report would have more information with
"Show verbose output during compilation"
option enabled in File -> Preferences.

Can someone suggest me what to do?
I have already changed The ic on the board

nithinmahendran:
I have already changed The ic on the board

By "ic", I assume you mean the ATmega328P. Did you buy an ATmega328P that was advertised as being pre-loaded with a bootloader? If not, you must connect an ISP programmer to your Uno and do a Tools > Burn Bootloader before you will be able to do normal uploads via USB to your Uno.

If you don't own a dedicated ISP programmer, you can use a spare Arduino board as an "Arduino as ISP":
https://www.arduino.cc/en/Tutorial/ArduinoISP