If you click on links we provide, we may receive compensation. TV Wanda Sykes, Margaret Cho, and more aren't playing around in truTV's Talk Show the Game Show By Nivea Serrao Published on March 13, 2017 12:02PM EDT If you watch late night talk shows for the games, get ready for the truTV two-in-one deal that is Talk Show the Game Show. Hosted by Guy Branum (The Mindy Project), the half-hour comedy series will pit celebrity guests against each other as they compete in talk show-inspired challenges and get judged — and roasted — by a panel of judges that include TV writer Karen Kilgariff (Portlandia) and journalist Casey Schreiner, who will deduct and award points based on their performances. The guest with the most points at the end of the night will win “Best Guest of the Night.” As you can see in the trailer above, the show’s 16-episode first season will feature a range of comedy veterans flexing their funny bones as they compete for the title, including Wanda Sykes, Margaret Cho, Paul Feig, Aasif Mandvi, and Oscar Nunez. 25 Funniest Game Show Bloopers Talk Show the Game Show will premiere on Wednesday, April 5 at 10 p.m. ET on truTV. Watch the trailer above and read on for the complete list of celebrity guests the show announced Monday. John Salley vs. Tiffany Haddish vs. Dan Bucatinsky Wanda Sykes vs. Scott Adsit vs. Pandora Boxx Maria Bamford vs. Ben Roy vs. James Adomian Diablo Cody vs. Moby vs. Arden Myrin Tim Bagley vs. Rashad Jennings vs. Beth Stelling Margaret Cho vs. Paul Feig vs. Ed Weeks John Early vs. Ana Navarro vs. Kate Flannery Utkarsh Ambudkar vs. Aparna Nancherla vs. Jon Daly Tracey Wigfield vs. TJ Lavin vs. Oscar Nunez Nicole Byer vs. Kyle Kinane vs. Julian McCullough Fortune Feimster vs. Adam Cayton-Holland vs. Alice Wetterlund Bridget Everett vs. Kelis vs. Josh McDermitt Wendi McLendon-Covey vs. Jonah Ray vs. Michelle Buteau John Ross Bowie vs. Aasif Mandvi vs. Phoebe Robinson Julie Klausner vs. Moshe Kasher vs. Rhea Butcher Chelsea Handler vs. Maurice Jones Drew vs. Nikki Glaser