Viralym-M is the lead therapeutic candidate in AlloVir's pipeline of
allogeneic, off-the-shelf multi-virus specific T-cell therapies designed to treat active virus-associated diseases in immunocompromised patients, including in patients following HSCT, solid organ transplant, or in patients suffering with primary immunodeficiencies, cancer, or HIV.
PNK-007 is an
allogeneic, off-the-shelf NK cell therapy being developed from placental hematopoietic stem cells as a potential treatment option for various hematologic cancers and solid tumors.
Haines, chief administrative officer, Celularity, said,"Celularity's IMPACT platform seamlessly integrates biosourcing through advanced cell manufacturing and productization of
allogeneic placental-derived cell therapeutics.
The core technology platform Stemchymal, using autologous and
allogeneic adipose mesenchymal stem cells, is backed by leading stem cell separation, purification, and proliferation technology.
Based on the growing knowledge on the immune system and T cell biology,
allogeneic HSCT also represents a promising approach in some solid tumors.
Allogeneic SCT was performed from his full-matched male donor during the accelerated phase.
Thus, UC-MSCs may represent an appealing cell source with a potential for clinical
allogeneic use to treat chondral, osteochondral lesions, and bone defects, being a possible candidate for a "universal off-the-shelf' stem cell product in the field of orthopaedic tissue engineering [13].
C3H
allogeneic and Balb/c syngeneic recipient mice were anesthetized and placed in lateral position.
The pattern of distribution of the
allogeneic cells throughout the recipient organism depends on such factors as the cell type, administration route and the immune response to transplantation (GAO et al., 2001; LIAO et al., 2008; LINDVALL & KOKAIA, 2010).
For co-culture of DCs and T cells,
allogeneic [CD4.sup.+] T cells were isolated from buffy coat using CD4 MicroBeads and 2 x [10.sup.5] cells/well co-cultured with 2 x [10.sup.4] cells/well DCs previously matured in the absence (C-mDCs) or presence (A-mDCs) of annotine at 100 [micro]g/ml.
We performed an
allogeneic HSCT because of the dismal prognosis and because delayed tumor regression after HSCT has been reported in a subset of adults with metastatic cancers, confirming the existence of a graft-versus-tumor effect in solid tumors [7].
Two men with chronic HIV-1 infection received
allogeneic hematopoietic stem cell transplants (HSCTs) from susceptible donors to treat Hodgkin's and non-Hodgkin's lymphoma, and achieved temporary remission of HIV despite stopping antiretroviral therapy (ART), with the virus undetectable in both blood and rectal mucosa.