affinity labeling


Also found in: Medical.

affinity labeling

[ə′fin·əd·ē ′lā·bə·liŋ]
(biochemistry)
A method for introducing a label into the active site of an enzyme by relying on the tight binding between the enzyme and its substrate (or cofactors).
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Among their topics are the role of reactive metabolites in genotoxicity, the bioactivation and inactivation of cytochrome P450 and other drug-metabolizing enzymes, intrinsically electrophilic compounds as a liability in drug discovery, the retrospective analysis of structure-toxicity relationships of drugs, experimental approaches to detecting reactive metabolites, structural alert and reactive metabolite analysis for the top 200 drugs in the US market by prescription, and mitigating toxicity risks with affinity labeling drug candidates.
Reactive drug metabolites
By affinity labeling in vivo, the lifetime of physiologically active entities can be greatly enhanced by becoming bound to long-lived blood components.
ConjuChem Biotechnologies obtains United States patent
1:00 Laura Parnas (UND): DOPAMINE TRANSPORTER LIGAND BINDING DOMAINS ANALYZED THROUGH PHOTO AFFINITY LABELING
Graduate communications in the A. Rodger Denison Competition
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