Raclopride

Raclopride
Clinical data
ATC code	none;
Pharmacokinetic data
Elimination half-life	20 min
Identifiers
	IUPAC name 3,5-dichloro-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide;
CAS Number	84225-95-6 ;
PubChem CID	3033769;
IUPHAR/BPS	94;
ChemSpider	2298373 ;
UNII	430K3SOZ7G;
ChEMBL	ChEMBL8809 ;
CompTox Dashboard (EPA)	DTXSID9045687 ;
Chemical and physical data
Formula	C15H20Cl2N2O3
Molar mass	347.236 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1c(O)c(c(OC)c(Cl)c1)C(=O)NC[C@H]2N(CC)CCC2;
	InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1 ; Key:WAOQONBSWFLFPE-VIFPVBQESA-N ;
	(what is this?) (verify)

Raclopride is a synthetic compound that acts as an antagonist on D2 dopamine receptors.^[1] It can be radiolabelled with the carbon-11 radioisotope and used in positron emission tomography (PET) scanning to assess the degree of dopamine binding to the D₂ Dopamine receptor. For example, one study found decreasing binding with the personality trait detachment.^[2] Radiolabelled raclopride is also commonly used to determine the efficacy and neurotoxicity of dopaminergic drugs.

References

^ C. Kohler, H. Hall, S. O. Ogren, L. Gawell (July 1985). "Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain". Biochemical Pharmacology. 34 (13): 2251–2259. doi:10.1016/0006-2952(85)90778-6. PMID 4015674.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Lars Farde, J. Petter Gustavsson, Erik Jönsson (February 1997). "D2 dopamine receptors and personality traits". Nature. 385 (6617): 590. doi:10.1038/385590a0. PMID 9024656.{{cite journal}}: CS1 maint: multiple names: authors list (link)

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.