Portal:Medicine

The Medicine Portal

The color fresco Care of The Sick by Domenico di Bartolo, 1441–1442, depicting the Santa Maria della Scala hospital in Siena, Italy

Medicine is the science and practice of caring for patients, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others.

Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of creativity and skill), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, or an ancient philosopher and physician would apply bloodletting according to the theories of humorism. In recent centuries, since the advent of modern science, most medicine has become a combination of art and science (both basic and applied, under the umbrella of medical science). For example, while stitching technique for sutures is an art learned through practice, knowledge of what happens at the cellular and molecular level in the tissues being stitched arises through science.

Prescientific forms of medicine, now known as traditional medicine or folk medicine, remain commonly used in the absence of scientific medicine and are thus called alternative medicine. Alternative treatments outside of scientific medicine with ethical, safety and efficacy concerns are termed quackery. (Full article...)

Featured articles -

Featured articles are displayed here, which represent some of the best content on English Wikipedia.

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  White in 1989

  
  Ryan Wayne White (December 6, 1971 – April 8, 1990) was an American teenager from Kokomo, Indiana, who became a national poster child for HIV/AIDS in the United States after his school barred him from attending classes following a diagnosis of AIDS.
  
  As a hemophiliac, White became infected with HIV from a contaminated factor VIII blood treatment and, when diagnosed in December 1984, was given six months to live. Doctors said he posed no risk to other students, as AIDS is not an airborne disease and spreads solely through bodily fluids, but AIDS was poorly understood by the general public at the time. When White tried to return to school, irate parents and teachers in Howard County rallied against his attendance due to unwarranted concerns of the disease spreading to other students and staff. A lengthy administrative appeal process ensued, and news of the conflict turned White into a popular celebrity and advocate for AIDS research and public education. Surprising his doctors, White lived five years longer than predicted. He died on April 8, 1990, one month before his high school graduation. (Full article...)
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  Dark Archives: A Librarian's Investigation into the Science and History of Books Bound in Human Skin is a 2020 non-fiction book by the medical librarian and death-positive advocate Megan Rosenbloom. Dealing with anthropodermic bibliopegy, the binding of books in human skin, it expounds upon Rosenbloom's research on such books and their historical, ethical, and cultural implications.
  
  The book focuses on the relationship between anthropodermic bibliopegy and the history of medicine; most confirmed cases of such books were created or owned by medical professionals, in contrast to common stereotypes that they were associated with Nazi Germany, serial killers, or the French Revolution. Rosenbloom discusses how the practice reflects the changing attitudes towards consent, ownership, and disposal of human bodies, and how the history of anthropodermic books intertwines with the history of medical ethics as a field. She interviews librarians, archivists, collectors, and experts on the topic, and examines notable examples of such books and their origins. Though Rosenbloom supports the preservation and maintenance of anthropodermic books, Dark Archives also covers arguments to the contrary, such as those espoused by Princeton University Library senior librarian Paul Needham. (Full article...)
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  A large flap lesion in the femur head typical of late stage Osteochondritis dissecans. In this case, the lesion was caused by avascular necrosis of the bone just under the cartilage.

  
  Osteochondritis dissecans (OCD or OD) is a joint disorder primarily of the subchondral bone in which cracks form in the articular cartilage and the underlying subchondral bone. OCD usually causes pain during and after sports. In later stages of the disorder there will be swelling of the affected joint that catches and locks during movement. Physical examination in the early stages does only show pain as symptom, in later stages there could be an effusion, tenderness, and a crackling sound with joint movement.
  
  
  OCD is caused by blood deprivation of the secondary physes around the bone core of the femoral condyle. This happens to the epiphyseal vessels under the influence of repetitive overloading of the joint during running and jumping sports. During growth such chondronecrotic areas grow into the subchondral bone. There it will show as bone defect area under articular cartilage. The bone will then possibly heal to the surrounding condylar bone in 50% of the cases. Or it will develop into a pseudarthrosis between condylar bone core and osteochondritis flake leaving the articular cartilage it supports prone to damage. The damage is executed by ongoing sport overload. The result is fragmentation (dissection) of both cartilage and bone, and the free movement of these bone and cartilage fragments within the joint space, causing pain, blockage and further damage. OCD has a typical anamnesis with pain during and after sports without any history of trauma. Some symptoms of late stages of osteochondritis dissecans are found with other diseases like rheumatoid disease of children and meniscal ruptures. The disease can be confirmed by X-rays, computed tomography (CT) or magnetic resonance imaging (MRI) scans. (Full article...)
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  Georges Gilles de la Tourette (1857–1904),
  namesake of Tourette syndrome

  
  Tourette syndrome or Tourette's syndrome (abbreviated as TS or Tourette's) is a common neurodevelopmental disorder that begins in childhood or adolescence. It is characterized by multiple movement (motor) tics and at least one vocal (phonic) tic. Common tics are blinking, coughing, throat clearing, sniffing, and facial movements. These are typically preceded by an unwanted urge or sensation in the affected muscles known as a premonitory urge, can sometimes be suppressed temporarily, and characteristically change in location, strength, and frequency. Tourette's is at the more severe end of a spectrum of tic disorders. The tics often go unnoticed by casual observers.
  
  Tourette's was once regarded as a rare and bizarre syndrome and has popularly been associated with coprolalia (the utterance of obscene words or socially inappropriate and derogatory remarks). It is no longer considered rare; about 1% of school-age children and adolescents are estimated to have Tourette's, though coprolalia occurs only in a minority. There are no specific tests for diagnosing Tourette's; it is not always correctly identified, because most cases are mild, and the severity of tics decreases for most children as they pass through adolescence. Therefore, many go undiagnosed or may never seek medical attention. Extreme Tourette's in adulthood, though sensationalized in the media, is rare, but for a small minority, severely debilitating tics can persist into adulthood. Tourette's does not affect intelligence or life expectancy. (Full article...)
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  McGill in her laboratory, 1942

  
  Frances Gertrude McGill (November 18, 1882 – January 21, 1959) was a Canadian forensic pathologist, criminologist, bacteriologist, allergologist and allergist. Nicknamed "the Sherlock Holmes of Saskatchewan" for her deductive skills and public fame, McGill influenced the development of forensic pathology in Canadian police work and was internationally noted for her expertise in the subject.
  
  After completing her medical degree at the University of Manitoba in 1915, McGill moved to Saskatchewan, where she was hired first as the provincial bacteriologist and then as the provincial pathologist. She worked extensively with the Royal Canadian Mounted Police (RCMP) and local police forces for more than thirty years, and was instrumental in establishing the first RCMP forensic laboratory. She directed the RCMP laboratory for three years, and trained new RCMP recruits in forensic detection methods. After retiring in 1946, McGill was appointed Honorary Surgeon for the RCMP by the Canadian Minister of Justice, becoming one of the first official female members of the force, and she continued to act as a consultant to the RCMP until her death in 1959. (Full article...)
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  Bupropion, formerly called amfebutamone, and sold under the brand name Wellbutrin among others, is an atypical antidepressant primarily used to treat major depressive disorder, seasonal affective disorder and to support smoking cessation. It is also popular as an add-on medication in the cases of "incomplete response" to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant. Bupropion has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction, it is not associated with weight gain and sleepiness, and it is more effective than SSRIs at improving symptoms of hypersomnia and fatigue. Bupropion, particularly the immediate release formulation, carries a higher risk of seizure than many other antidepressants, hence caution is recommended in patients with a history of seizure disorder. The medication is taken by mouth.
  
  
  Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Raised blood pressure is notable. Rare but serious side effects include seizures, liver toxicity, psychosis, and risk of overdose. Bupropion use during pregnancy may be associated with increased likelihood of congenital heart defects. (Full article...)
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  The 1966 New York City smog was a major air-pollution episode and environmental disaster, coinciding with that year's Thanksgiving holiday weekend. Smog covered the city and its surrounding area from November 23 to 26, filling the city's air with damaging levels of several toxic pollutants. It was the third major smog in New York City, following events of similar scale in 1953 and 1963.
  
  On November 23, a large mass of stagnant air over the East Coast trapped pollutants in the city's air. For three days, New York City was engulfed in dangerously high levels of carbon monoxide, sulfur dioxide, smoke, and haze. Pockets of air pollution pervaded the greater New York metropolitan area, including parts of New Jersey and Connecticut. By November 25, the smog became severe enough that regional leaders announced a "first-stage alert". During the alert, leaders of local and state governments asked residents and industry to take voluntary steps to minimize emissions. Health officials advised people with respiratory or heart conditions to remain indoors. The city shut off garbage incinerators, requiring massive hauling of garbage to landfills. A cold front dispersed the smog on November 26, and the alert ended. (Full article...)
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  Microscopic image of a Lewy body (adjacent to arrowhead) in a neuron of the substantia nigra; scale bar=20 microns (0.02 mm)

  
  Dementia with Lewy bodies (DLB) is a type of dementia characterized by changes in sleep, behavior, cognition, movement, and regulation of automatic bodily functions. Memory loss is not always an early symptom. The disease worsens over time and is usually diagnosed when cognitive impairment interferes with normal daily functioning. Together with Parkinson's disease dementia, DLB is one of the two Lewy body dementias. It is a common form of dementia, but the prevalence is not known accurately and many diagnoses are missed. The disease was first described on autopsy by Kenji Kosaka in 1976, and he named the condition several years later.
  
  REM sleep behavior disorder (RBD)—in which people lose the muscle paralysis (atonia) that normally occurs during REM sleep and act out their dreams—is a core feature. RBD may appear years or decades before other symptoms. Other core features are visual hallucinations, marked fluctuations in attention or alertness, and parkinsonism (slowness of movement, trouble walking, or rigidity). A presumptive diagnosis can be made if several disease features or biomarkers are present; the diagnostic workup may include blood tests, neuropsychological tests, imaging, and sleep studies. A definitive diagnosis usually requires an autopsy. (Full article...)
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  A CBC specimen in front of a printout displaying CBC and differential results

  
  A complete blood count (CBC), also known as a full blood count (FBC), is a set of medical laboratory tests that provide information about the cells in a person's blood. The CBC indicates the counts of white blood cells, red blood cells and platelets, the concentration of hemoglobin, and the hematocrit (the volume percentage of red blood cells). The red blood cell indices, which indicate the average size and hemoglobin content of red blood cells, are also reported, and a white blood cell differential, which counts the different types of white blood cells, may be included.
  
  The CBC is often carried out as part of a medical assessment and can be used to monitor health or diagnose diseases. The results are interpreted by comparing them to reference ranges, which vary with sex and age. Conditions like anemia and thrombocytopenia are defined by abnormal complete blood count results. The red blood cell indices can provide information about the cause of a person's anemia such as iron deficiency and vitamin B12 deficiency, and the results of the white blood cell differential can help to diagnose viral, bacterial and parasitic infections and blood disorders like leukemia. Not all results falling outside of the reference range require medical intervention. (Full article...)
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  Computer–aided reconstruction of a rotavirus based on several electron micrographs

  
  Rotaviruses are the most common cause of diarrhoeal disease among infants and young children. Nearly every child in the world is infected with a rotavirus at least once by the age of five. Immunity develops with each infection, so subsequent infections are less severe. Adults are rarely affected. Rotavirus is a genus of double-stranded RNA viruses in the family Reoviridae. There are nine species of the genus, referred to as A, B, C, D, F, G, H, I and J. Rotavirus A is the most common species, and these rotaviruses cause more than 90% of rotavirus infections in humans.
  
  The virus is transmitted by the faecal–oral route. It infects and damages the cells that line the small intestine and causes gastroenteritis (which is often called "stomach flu" despite having no relation to influenza). Although rotavirus was discovered in 1973 by Ruth Bishop and her colleagues by electron micrograph images and accounts for approximately one third of hospitalisations for severe diarrhoea in infants and children, its importance has historically been underestimated within the public health community, particularly in developing countries. In addition to its impact on human health, rotavirus also infects other animals, and is a pathogen of livestock. (Full article...)
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  Menstrual cycle

  
  The menstrual cycle is a series of natural changes in hormone production and the structures of the uterus and ovaries of the female reproductive system that makes pregnancy possible. The ovarian cycle controls the production and release of eggs and the cyclic release of estrogen and progesterone. The uterine cycle governs the preparation and maintenance of the lining of the uterus (womb) to receive an embryo. These cycles are concurrent and coordinated, normally last between 21 and 35 days, with a median length of 28 days. Menarche (the onset of the first period) usually occurs around the age of 12 years; menstrual cycles continue for about 30–45 years.
  
  Naturally occurring hormones drive the cycles; the cyclical rise and fall of the follicle stimulating hormone prompts the production and growth of oocytes (immature egg cells). The hormone estrogen stimulates the uterus lining (endometrium) to thicken to accommodate an embryo should fertilization occur. The blood supply of the thickened lining provides nutrients to a successfully implanted embryo. If implantation does not occur, the lining breaks down and blood is released. Triggered by falling progesterone levels, menstruation (a "period", in common parlance) is the cyclical shedding of the lining, and is a sign that pregnancy has not occurred. (Full article...)
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  Major General Rupert Major Downes, CMG, KStJ, VD, FRACS (10 February 1885 – 5 March 1945) was an Australian soldier, surgeon and historian.
  
  The son of British Army officer Major Francis Downes, Downes joined the Army as a trumpeter while he was still at school. He attended the University of Melbourne, graduating with his medical degrees in 1907 and a Doctor of Medicine degree in 1911. He was commissioned as a captain in the Australian Army Medical Corps in 1908, and after the outbreak of the First World War he joined the First Australian Imperial Force (AIF) in 1914 as its youngest lieutenant colonel. He served in the Gallipoli campaign, and was appointed Assistant Director of Medical Services (ADMS) of the newly formed Anzac Mounted Division in 1916, which he combined with the post of ADMS AIF Egypt. In 1917, he became Deputy Director of Medical Services (DDMS) of the Desert Mounted Corps. After the war, he wrote articles on medical aspects of the Sinai and Palestine campaign, and the section on the campaign for the Official History of Australia in the War of 1914–1918. (Full article...)
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  Influenza virus

  
  Influenza, commonly known as the flu, is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin one to four (typically two) days after exposure to the virus and last for about two to eight days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia from the virus or a subsequent bacterial infection. Other complications include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease.
  
  There are four types of influenza virus: types A, B, C, and D. Aquatic birds are the primary source of influenza A virus (IAV), which is also widespread in various mammals, including humans and pigs. Influenza B virus (IBV) and influenza C virus (ICV) primarily infect humans, and influenza D virus (IDV) is found in cattle and pigs. Influenza A virus and influenza B virus circulate in humans and cause seasonal epidemics, and influenza C virus causes a mild infection, primarily in children. Influenza D virus can infect humans but is not known to cause illness. In humans, influenza viruses are primarily transmitted through respiratory droplets from coughing and sneezing. Transmission through aerosols and surfaces contaminated by the virus also occur. (Full article...)
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  A CT scan showing a pulmonary contusion (red arrow) accompanied by a rib fracture (purple arrow)

  
  A pulmonary contusion, also known as lung contusion, is a bruise of the lung, caused by chest trauma. As a result of damage to capillaries, blood and other fluids accumulate in the lung tissue. The excess fluid interferes with gas exchange, potentially leading to inadequate oxygen levels (hypoxia). Unlike pulmonary laceration, another type of lung injury, pulmonary contusion does not involve a cut or tear of the lung tissue.
  
  
  A pulmonary contusion is usually caused directly by blunt trauma but can also result from explosion injuries or a shock wave associated with penetrating trauma. With the use of explosives during World Wars I and II, pulmonary contusion resulting from blasts gained recognition. In the 1960s its occurrence in civilians began to receive wider recognition, in which cases it is usually caused by traffic accidents. The use of seat belts and airbags reduces the risk to vehicle occupants. (Full article...)
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  Tatsuguchi soon after his induction into the Imperial Japanese Army in 1941 and his initial assignment to the First Imperial Guard Regiment in Tokyo

  Paul Nobuo Tatsuguchi (辰口 信夫, Tatsuguchi Nobuo), sometimes mistakenly referred to as Nebu Tatsuguchi (August 31, 1911 – May 30, 1943), was a Japanese soldier and surgeon who served in the Imperial Japanese Army (IJA) during World War II. He was killed during the Battle of Attu on Attu Island, Alaska, United States, on May 30, 1943.
  
  A devout Seventh-day Adventist, Tatsuguchi studied medicine and was licensed as a physician in the United States (US). He returned to his native Japan to practice medicine at the Tokyo Adventist Sanitarium, where he received further medical training. In 1941, he was ordered to cease his medical practice and conscripted into the IJA as an acting medical officer, although he was given an enlisted rather than officer rank because of his American connections. In late 1942, Tatsuguchi was sent to Attu, which had been occupied by Japanese forces in June 1942. On May 11, 1943, The United States Army landed on the island, intending to retake American soil from the Japanese. (Full article...)

Selected image –

Horizontal optokinetic reflex, a form of physiologic nystagmus.

Photo credit: Student BSMU, GFDL

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  An X-ray demonstrating the characteristic finding of lead poisoning in humans—dense metaphyseal lines

  
  Lead poisoning, also known as plumbism and saturnism, is a type of metal poisoning caused by lead in the body. Symptoms may include abdominal pain, constipation, headaches, irritability, memory problems, infertility, and tingling in the hands and feet. It causes almost 10% of intellectual disability of otherwise unknown cause and can result in behavioral problems. Some of the effects are permanent. In severe cases, anemia, seizures, coma, or death may occur.
  
  
  Exposure to lead can occur by contaminated air, water, dust, food, or consumer products. Lead poisoning poses a significantly increased risk to children as they are far more likely to ingest lead indirectly by chewing on toys or other objects that are coated in lead paint. Additionally, children absorb greater quantities of lead from ingested sources than adults. Exposure at work is a common cause of lead poisoning in adults with certain occupations at particular risk. Diagnosis is typically by measurement of the blood lead level. The Centers for Disease Control and Prevention (US) has set the upper limit for blood lead for adults at 10 μg/dL (10 μg/100 g) and for children at 3.5 μg/dL; before October 2021 the limit was 5 μg/dL. Elevated lead may also be detected by changes in red blood cells or dense lines in the bones of children as seen on X-ray. (Full article...)
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  Reconstruction of the trachea and bronchi with x-ray computed tomography showing disruption of the right main bronchus with abnormal lucency (arrow)

  
  Tracheobronchial injury is damage to the tracheobronchial tree (the airway structure involving the trachea and bronchi). It can result from blunt or penetrating trauma to the neck or chest, inhalation of harmful fumes or smoke, or aspiration of liquids or objects.
  
  
  Though rare, TBI is a serious condition; it may cause obstruction of the airway with resulting life-threatening respiratory insufficiency. Other injuries accompany TBI in about half of cases. Of those people with TBI who die, most do so before receiving emergency care, either from airway obstruction, exsanguination, or from injuries to other vital organs. Of those who do reach a hospital, the mortality rate may be as high as 30%. (Full article...)
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  Neuroacanthocytosis is a label applied to several genetic neurological conditions in which the blood contains misshapen, spiculated red blood cells called acanthocytes.
  
  The 'core' neuroacanthocytosis syndromes, in which acanthocytes are a typical feature, are chorea acanthocytosis and McLeod syndrome. Acanthocytes are seen less frequently in other conditions including Huntington's disease-like syndrome 2 (HDL2) and pantothenate kinase-associated neurodegeneration (PKAN). (Full article...)
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  Willis John Potts (March 22, 1895 – May 5, 1968) was an American pediatric surgeon and one of the earliest physicians to focus on the surgical treatment of heart problems in children. Potts set up one of the country's first pediatric surgery programs at Children's Memorial Hospital (later renamed Lurie Children's Hospital) in Chicago.
  
  A graduate of the University of Chicago and Rush Medical College, Potts was known for introducing a surgery to address the heart defects that resulted in blue baby syndrome; the procedure became known as the Potts shunt. In addition, Potts performed the first successful repair of a cardiovascular abnormality known as a pulmonary artery sling. He also invented several surgical instruments, with a particular emphasis on devices used in surgery on major blood vessels. (Full article...)
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  Charles Lester Leonard (1861–1913) was an American physician and X-ray pioneer. Leonard was the first radiologist at the Hospital of the University of Pennsylvania, founded the Philadelphia Roentgen Ray Society, and served as president of the American Roentgen Ray Society in 1904–1905. He was known as one of the foremost experts in urological X-ray diagnosis, and he was the first American physician to demonstrate kidney stone disease with X-rays.
  
  A native of Massachusetts, Leonard completed bachelor's degrees at the University of Pennsylvania and Harvard University, then returned to Penn for medical school. As a student, he was interested in photography, and after going to Europe to work in science laboratories, he developed an interest in photomicrography. Leonard captured microscopic images that furthered the understanding of the life cycles of microorganisms. (Full article...)
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  Soldiers sick with Spanish flu at a hospital ward at Camp Funston in Fort Riley, Kansas

  
  The 1918–1920 flu pandemic, also known as the Great Influenza epidemic or by the common misnomer Spanish flu, was an exceptionally deadly global influenza pandemic caused by the H1N1 subtype of the influenza A virus. The earliest documented case was March 1918 in the state of Kansas in the United States, with further cases recorded in France, Germany and the United Kingdom in April. Two years later, nearly a third of the global population, or an estimated 500 million people, had been infected in four successive waves. Estimates of deaths range from 17 million to 50 million, and possibly as high as 100 million, making it one of the deadliest pandemics in history.
  
  The pandemic broke out near the end of World War I, when wartime censors in the belligerent countries suppressed bad news to maintain morale, but newspapers freely reported the outbreak in neutral Spain, creating a false impression of Spain as the epicenter and leading to the "Spanish flu" misnomer. Limited historical epidemiological data make the pandemic's geographic origin indeterminate, with competing hypotheses on the initial spread. (Full article...)
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  General skeletal formula of cobalamins

  
  Vitamin B₁₂, also known as cobalamin, is a water-soluble vitamin involved in metabolism. It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. It is important in the normal functioning of the nervous system via its role in the synthesis of myelin, and in the circulatory system in the maturation of red blood cells in the bone marrow. Plants do not need cobalamin and carry out the reactions with enzymes that are not dependent on it.
  
  Vitamin B₁₂ is the most chemically complex of all vitamins, and for humans the only vitamin that must be sourced from animal-derived foods or supplements. Only some archaea and bacteria can synthesize vitamin B₁₂. Vitamin B₁₂ deficiency is a widespread condition that is particularly prevalent in populations with low consumption of animal foods. Such diets can be due to a variety of reasons, such as low socioeconomic status, ethical considerations, or lifestyle choices such as veganism. (Full article...)
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  Community health worker preparing a vaccine in Odisha, India

  
  
  Women's health in India can be examined in terms of multiple indicators, which vary by geography, socioeconomic standing and culture. To adequately improve the health of women in India multiple dimensions of wellbeing must be analysed in relation to global health averages and also in comparison to men in India. Health is an important factor that contributes to human wellbeing and economic growth.
  
  Currently, women in India face a multitude of health problems, which ultimately affect the aggregate economy's output. Addressing the gender, class or ethnic disparities that exist in healthcare and improving the health outcomes can contribute to economic gain through the creation of quality human capital and increased levels of savings and investment. (Full article...)
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  Basic Medicine (Korean: 기초의학; MR: Kich'o ŭihak) is a North Korean quarterly general medical journal established in 1969 and published by the Science and Encyclopedia Publishing House (과학백과사전출판사). The journal is subject to widespread publication bias and does not meet international standards; it lacks peer review, in-line citations, and an ethical code. Basic Medicine is produced primarily for domestic distribution, although it is one of ten North Korean medical journals available in South Korea. (Full article...)
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  The Corrupted Blood incident (also known as the World of Warcraft pandemic) took place between September 13 and October 8, 2005, in World of Warcraft, a massively multiplayer online role-playing game (MMORPG) developed by Blizzard Entertainment. When participating in a certain boss battle at the end of a raid, player characters would become infected with a debuff that was transmitted between characters in close proximity. While developers intended to keep the effects of the debuff within this boss's game region, a programming oversight soon led to an in-game pandemic throughout the fictional world of Azeroth.
  
  World of Warcraft introduced the game region of Zul'Gurub on September 13. The boss of the region, Hakkar the Soulflayer, cast the debuff Corrupted Blood on raid participants, which expired when players defeated Hakkar. Corrupted Blood soon spread beyond Zul'Gurub through players deactivating their infected animal companions, who when reactivated in densely populated non-combat zones, still carried the debuff, becoming disease vectors, while non-player characters became asymptomatic carriers. Player reactions to the Corrupted Blood pandemic varied: some provided aid by healing players or warning them of outbreak zones, while griefers intentionally contracted the debuff to spread it across the game world. After several failed hotfixes, Blizzard ended the pandemic by performing a hard reset, and a later patch prevented companions from contracting Corrupted Blood entirely. (Full article...)
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  Pain in cancer may arise from a tumor compressing or infiltrating nearby body parts; from treatments and diagnostic procedures; or from skin, nerve and other changes caused by a hormone imbalance or immune response. Most chronic (long-lasting) pain is caused by the illness and most acute (short-term) pain is caused by treatment or diagnostic procedures. However, radiotherapy, surgery and chemotherapy may produce painful conditions that persist long after treatment has ended.
  
  The presence of pain depends mainly on the location of the cancer and the stage of the disease. At any given time, about half of all people diagnosed with malignant cancer are experiencing pain, and two-thirds of those with advanced cancer experience pain of such intensity that it adversely affects their sleep, mood, social relations and activities of daily living. (Full article...)
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  Electron micrograph of hepatitis C virus from cell culture (scale = 50 nanometers)

  
  Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection period, people often have mild or no symptoms. Early symptoms can include fever, dark urine, abdominal pain, and yellow tinged skin. The virus persists in the liver, becoming chronic, in about 70% of those initially infected. Early on, chronic infection typically has no symptoms. Over many years however, it often leads to liver disease and occasionally cirrhosis. In some cases, those with cirrhosis will develop serious complications such as liver failure, liver cancer, or dilated blood vessels in the esophagus and stomach.
  
  HCV is spread primarily by blood-to-blood contact associated with injection drug use, poorly sterilized medical equipment, needlestick injuries in healthcare, and transfusions. In regions where blood screening has been implemented, the risk of contracting HCV from a transfusion has dropped substantially to less than one per two million. HCV may also be spread from an infected mother to her baby during birth. It is not spread through breast milk, food, water or casual contact such as hugging, kissing and sharing food or drinks with an infected person. It is one of five known hepatitis viruses: A, B, C, D, and E.
  Diagnosis is by blood testing to look for either antibodies to the virus or viral RNA. In the United States, screening for HCV infection is recommended in all adults age 18 to 79 years old.
  There is no vaccine against hepatitis C. Prevention includes harm reduction efforts among people who inject drugs, testing donated blood, and treatment of people with chronic infection. Chronic infection can be cured more than 95% of the time with antiviral medications such as sofosbuvir or simeprevir. Peginterferon and ribavirin were earlier generation treatments that proved successful in <50% of cases and caused greater side effects. While access to the newer treatments was expensive, by 2022 prices had dropped dramatically in many countries (primarily low-income and lower-middle-income countries) due to the introduction of generic versions of medicines. Those who develop cirrhosis or liver cancer may require a liver transplant. Hepatitis C is one of the leading reasons for liver transplantation, though the virus usually recurs after transplantation. (Full article...)
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  Nessa Carey at Eastbourne Sceptics in the Pub in February 2015 after her Epigenetics talk.

  
  Nessa Carey is a British biologist working in the field of molecular biology and biotechnology. She is International Director of the technology transfer organization PraxisUnico and a visiting professor at Imperial College London.
  
  With expertise in the field of epigenetics and in technology transfer, she promotes the movement of scientists between academia and industry, lecturing often to school students and early career scientists. Carey writes books and articles for a scientifically interested general audience. She is the author of The Epigenetics Revolution and Junk DNA: A Journey Through the Dark Matter of the Genome which explore advances in the field of epigenetics and their implications for medicine. She edited Epigenetics for Drug Discovery for the Royal Society of Chemistry's Drug Discovery Series. (Full article...)
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  Carbon monoxide

  
  Carbon monoxide poisoning typically occurs from breathing in carbon monoxide (CO) at excessive levels. Symptoms are often described as "flu-like" and commonly include headache, dizziness, weakness, vomiting, chest pain, and confusion. Large exposures can result in loss of consciousness, arrhythmias, seizures, or death. The classically described "cherry red skin" rarely occurs. Long-term complications may include chronic fatigue, trouble with memory, and movement problems.
  
  
  CO is a colorless and odorless gas which is initially non-irritating. It is produced during incomplete burning of organic matter. This can occur from motor vehicles, heaters, or cooking equipment that run on carbon-based fuels. Carbon monoxide primarily causes adverse effects by combining with hemoglobin to form carboxyhemoglobin (symbol COHb or HbCO) preventing the blood from carrying oxygen and expelling carbon dioxide as carbaminohemoglobin. Additionally, many other hemoproteins such as myoglobin, Cytochrome P450, and mitochondrial cytochrome oxidase are affected, along with other metallic and non-metallic cellular targets. (Full article...)
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  Canker sore on the lower lip

  
  Aphthous stomatitis, or recurrent aphthous stomatitis (RAS), commonly referred to as a canker sore, is a common condition characterized by the repeated formation of benign and non-contagious mouth ulcers (aphthae) in otherwise healthy individuals.
  
  The cause is not completely understood but involves a T cell-mediated immune response triggered by a variety of factors which may include nutritional deficiencies, local trauma, stress, hormonal influences, allergies, genetic predisposition, certain foods, dehydration, some food additives, or some hygienic chemical additives like SDS (common in toothpaste). (Full article...)

Did you know –

• ... vinca alkaloids are chemotherapy drugs that inhibit the polymerization of tubulin, whereas taxanes are produced by plants of the genus Taxus that inhibit tubulin depolymerization?

• ... that Sydenham's chorea (or St. Vitus' dance) is one of the major criteria in the Jones diagnostic criteria for rheumatic fever?
• ... that rare mistargetting of somatic hypermutation is being investigated as a mechanism in the development of B-cell lymphomas?

General images –

The following are images from various Medicine-related articles on Wikipedia.

• 
  Guy's Hospital in 1820 (from History of medicine)
• 
  Life expectancy vs healthcare spending of rich OECD countries. US average of $10,447 in 2018. (from Health care)
• 
  Louis Pasteur experimenting on bacteria, c. 1870 (from History of medicine)
• 
  A Ukrainian monument to the HIV pandemic. (from History of medicine)
• 
  Infographic showing how healthcare data flows within the billing process (from Medical billing)
• 
  Health expenditure funding types (from Health insurance)
• 
  The numbers of Americans lacking health insurance and the uninsured rate from 1987 to 2008 (from Health insurance)
• 
  Seven named physicians and botanists of the Classical world from Vienna Dioscurides. Clockwise from top center: Galen, Dioscorides, Nicander, Rufus of Ephesus, Andreas of Carystus, Apollonius Mus or of Pergamon, Crateuas (from History of medicine)
• 
  Smallpox vaccination in Niger, 1969. A decade later, this was the first infectious disease to be eradicated. (from History of medicine)
• 
  Health spending by country. Percent of GDP (Gross domestic product). For example: 11.2% for Canada in 2022. 16.6% for the United States in 2022. (from Health care)
• 
  The emergency room is often a frontline venue for the delivery of primary medical care. (from Health care)
• 
  A 12th-century Byzantine manuscript of the Hippocratic Oath (from Medical ethics)
• 
  Statue of Robert Koch, father of medical bacteriology, at Robert-Koch-Platz (Robert Koch square) in Berlin (from History of medicine)
• 
  Galen (129–216 CE), known for his wide insights into anatomy. (from History of medicine)
• 
  Health Expenditure per capita (in PPP-adjusted US$) among several OECD member nations. Data source: OECD's iLibrary (from Health insurance)
• 
  Primary care may be provided in community health centers. (from Health care)
• 
  Zhang Zhongjing – a Chinese pharmacologist, physician, inventor, and writer of the Eastern Han dynasty. (from History of medicine)
• 
  Hospital train "Therapist Matvei Mudrov" in Khabarovsk, Russia (from Health care)
• 
  Life Expectancy of the total population at birth among several OECD member nations. Data source: OECD's iLibrary (from Health insurance)
• 
  Magical stela or cippus of Horus inscribed with healing encantations (c. 332 to 280 BCE). (from History of medicine)
• 
  Ethical prayer for medical wisdom by Dr Edmond Fernandes (from Medical ethics)
• 
  Yarrow, a medicinal plant found in human-occupied caves in the Upper Palaeolithic period. (from History of medicine)
• 
  American combat surgery during the Pacific War, 1943 (from History of medicine)
• 
  Emil Kraepelin (1856–1926), the founder of modern scientific psychiatry, psychopharmacology and psychiatric genetics. (from History of medicine)
• 
  A 12th-century manuscript of the Hippocratic Oath in Greek, one of the most famous aspects of classical medicine that carried into later eras (from History of medicine)
• 
  healthcare expenditure in Japan by age group (from Health insurance)
• 
  Medical personnel place sterilized covers on the arms of the daVinci Xi surgical system, a minimally-invasive robotic surgery system, at the William Beaumont Army Medical Center. (from History of medicine)
• 
  18th-century medical remedies collected by a British Gentry family (from History of medicine)
• 
  Sometimes traditional medicines include parts of endangered species, such as the slow loris in Southeast Asia. (from Traditional medicine)
• 
  The plinthios brochos as described by Greek physician Heraklas, a sling for binding a fractured jaw. These writings were preserved in one of Oribasius' collections. (from History of medicine)
• 
  Replica of Antonie van Leeuwenhoek's microscope of the 1670s (from History of medicine)
• 
  AMA Code of Medical Ethics (from Medical ethics)
• 
  Mandrake (written 'ΜΑΝΔΡΑΓΟΡΑ' in Greek capitals). Naples Dioscurides, 7th century (from History of medicine)
• 
  Patient, Surrey County Lunatic Asylum, c. 1850–58. The asylum population in England and Wales rose from 1,027 in 1827 to 74,004 in 1900. (from History of medicine)
• 
  American Civil War hospital at Gettysburg, 1863 (from History of medicine)
• 
  Total healthcare cost per person. Public and private spending. US dollars PPP. For example: $6,319 for Canada in 2022. $12,555 for the US in 2022. (from Health care)
• 
  An American billing clerk preparing a detailed invoice. (1992) (from Medical billing)
• 
  COVID-19 swab testing in Rwanda (2021). (from History of medicine)
• 
  Jackson Memorial Hospital in Miami, the primary teaching hospital of the University of Miami's Miller School of Medicine and the largest hospital in the United States with 1,547 beds (from Health care)
• 
  A cochlear implant is a common kind of neural prosthesis, a device replacing part of the human nervous system. (from History of medicine)
• 
  Hippocrates (c. 460–370 BCE). Known as the "father of medicine". (from History of medicine)
• 
  Taoist symbol of Yin and Yang (from Medical ethics)
• 
  Global concentrations of health care resources, as depicted by the number of physicians per 10,000 individuals, by country. Data is sourced from a World Health Statistics 2010, a WHO report. (from Health care)
• 
  Charite in Berlin (from History of medicine)
• 
  "More Doctors Smoke Camels than Any Other Cigarette" advertisement for Camel cigarettes in the 1940s (from Medical ethics)
• 
  A cuneiform terracotta tablet describing a medicinal recipe for poisoning (c. 18th century BCE). Discovered in Nippur, Iraq.
• 
  Depiction of smallpox in Franciscan Bernardino de Sahagún's history of the conquest of Mexico, Book XII of the Florentine Codex, from the defeated Aztecs' point of view (from History of medicine)
• 
  Medicine during the First World War - Medical Transport. (from History of medicine)
• 
  "Diagram of the causes of mortality in the army in the East" by Florence Nightingale. (from History of medicine)
• 
  A Neo-Assyrian cuneiform tablet fragment describing medical text (c. 9th to 7th century BCE). (from History of medicine)
• 
  Curandera performing a limpieza in Cuenca, Ecuador (from Traditional medicine)
• 
  The Edwin Smith Surgical Papyrus, written in the 17th century BCE, contains the earliest recorded reference to the brain. New York Academy of Medicine. (from History of medicine)
• 
  Traditional medicine in a market in Antananarivo, Madagascar (from Traditional medicine)
• 
  National Hospital for Neurology and Neurosurgery in London, United Kingdom is a specialist neurological hospital. (from Health care)
• 
  Botánicas such as this one in Jamaica Plain, Boston, cater to the Latino community and sell folk medicine alongside statues of saints, candles decorated with prayers, lucky bamboo, and other items. (from Traditional medicine)
• 
  Sketch of Muslim physician Muhammad ibn Zakariya al-Razi (from History of medicine)
• 
  Most countries have seen a tremendous increase in life expectancy since 1945. However, in southern Africa, the HIV epidemic beginning around 1990 has eroded national health. (from History of medicine)
• 
  The Quaker-run York Retreat, founded in 1796, gained international prominence as a centre for moral treatment and a model of asylum reform following the publication of Samuel Tuke's Description of the Retreat (1813). (from History of medicine)
• 
  Mexico City epidemic of 1737, with elites calling on the Virgin of Guadalupe (from History of medicine)
• 
  A doctor checks a patient's pulse in Meiji-era Japan. (from History of medicine)

More Did you know (auto generated)

• ... that Constance Fozzard was told during her surgical training that women with children could not become consultants?
• ... that a lack of screening for pregnant women with syphilis in sub-Saharan Africa is associated with increased infant mortality?
• ... that Margaret C. Roberts was encouraged to study medicine by LDS Church leader Brigham Young to reduce mortality rates during childbirth?
• ... that the Noongar used the Eucalyptus wandoo tree as a medicine and ointment?
• ... that Tang Zonghai was one of the first advocates for the integration of Chinese and Western medicine?
• ... that the Anglo-Saxons may have used a mixture of garlic, another Allium, wine, and bovine bile as an eye medicine?

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