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List of Schedule IV controlled substances (U.S.)

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This is the list of Schedule IV controlled substances in the United States as defined by the Controlled Substances Act.[1] The following findings are required for substances to be placed in this schedule:[2]

  1. The drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule III.
  2. The drug or other substance has a currently accepted medical use in treatment in the United States.
  3. Abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule III.

The complete list of Schedule IV substances is as follows. The Administrative Controlled Substances Code Number and Federal Register citation for each substance is included.

Narcotics

[edit]
ACSCN Drug
9167 Not more than 1 milligram of difenoxin and not less than 25 micrograms of atropine sulfate per dosage unit.[3]
9278 Dextropropoxyphene[4]
9752 Tramadol[5]

Depressants

[edit]
ACSCN Drug
2731 Alfaxalone[6]
2882 Alprazolam[7]
2145 Barbital[8][note 1]
2400 Brexanolone[9]
2748 Bromazepam[10]
2749 Camazepam[10]
8192 Carisoprodol[11]
2460 Chloral betaine[8][note 1]
2465 Chloral hydrate[8][note 1]
2744 Chlordiazepoxide[12]
2751 Clobazam[10]
2737 Clonazepam[12]
2768 Clorazepate[12]
2752 Clotiazepam[10]
2753 Cloxazolam[10]
2410 Daridorexant[13]
2754 Delorazepam[10]
2765 Diazepam[12]
2467 Dichloraphenazone[14]
2756 Estazolam[10]
2540 Ethchlorvynol[8][note 1]
2545 Ethinamate[8][note 1]
2758 Ethyl loflazepate[10]
2759 Fludiazepam[10]
2763 Flunitrazepam† [10]
2767 Flurazepam[12]
2138 Fospropofol[15]
2762 Halazepam[16]
2771 Haloxazolam[10]
2772 Ketazolam[10]
2245 Lemborexant[17]
2773 Loprazolam[10]
2885 Lorazepam[18]
2774 Lormetazepam[10]
2800 Mebutamate[19]
2836 Medazepam[10]
2820 Meprobamate[8][note 1]
2264 Methohexital[8][note 1]
2250 Methylphenobarbital (mephobarbital)[8][note 1]
2884 Midazolam[20]
2837 Nimetazepam[10]
2834 Nitrazepam[10]
2838 Nordiazepam[10]
2835 Oxazepam[12]
2839 Oxazolam[10]
2585 Paraldehyde[8][note 1]
2591 Petrichloral[8][note 1]
2285 Phenobarbital[8][note 1]
2883 Pinazepam[10]
2764 Prazepam[21]
2881 Quazepam[20]
2846 Remimazolam[22]
2223 Suvorexant[23]
2925 Temazepam†[24]
2886 Tetrazepam[10]
2887 Triazolam[25]
2781 Zaleplon[26]
2783 Zolpidem[27]
2784 Zopiclone[28]
2420 Zuranolone[29]

†Flunitrazepam has not been approved by the Food and Drug Administration for medical use, and is considered to be an illegal drug.

†Temazepam may require a specially coded prescription in certain States.

Lorcaserin

[edit]
ACSCN Drug
1625 Lorcaserin[30]

Stimulants

[edit]
ACSCN Drug
1230 Cathine[31]
1610 Diethylpropion[32]
1760 Fencamfamin[31]
1575 Fenproporex[31]
1605 Mazindol[33]
1580 Mefenorex[31]
1680 Modafinil and enantiopure armodafinil[34]
1530 Pemoline[35]
1640 Phentermine[32]
1750 Pipradrol[36]
1729 Serdexmethylphenidate[37]
1675 Sibutramine[38]
1650 Solriamfetol[39]
1635 SPA / (-)-1-dimethylamino- 1,2-diphenylethane[36]

Others

[edit]
ACSCN Drug
9709 Pentazocine[40]
9720 Butorphanol[41]
9725 Eluxadoline[42]

See also

[edit]

Notes

[edit]
  1. ^ a b c d e f g h i j k This substance was expressly scheduled by the Controlled Substances Act on October 27, 1970. The 1974 Federal Register ruling (by Administrator John R. Bartels, Jr.) merely organized its listing in the Code of Federal Regulations.

References

[edit]
  1. ^ "21 CFR 1308.14 (Schedule IV)". Code of Federal Regulations. Retrieved September 9, 2023.
  2. ^ 21 U.S.C. § 812(b)(4) retrieved October 2, 2007
  3. ^ Bensinger, Peter (August 28, 1978). "Placement of Preparations Containing Difenoxin in Combination With Atropine Sulfate Into Schedules IV and V" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  4. ^ Bensinger, Peter (July 24, 1980). "Classification of Dextropropoxyphene as a Narcotic Drug in Schedule IV of the Controlled Substances Act" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  5. ^ Harrigan, Thomas (July 2, 2014). "Schedules of Controlled Substances: Placement of Tramadol Into Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  6. ^ Leonhart, Michele (February 27, 2014). "Schedules of Controlled Substances: Placement of Alfaxalone into Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  7. ^ Mullen, Jr., Francis M. (November 12, 1981). "Schedules of Controlled Substsnces; Placement of Alprazolam in Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  8. ^ a b c d e f g h i j k Bartels Jr., John R. (June 20, 1974). "PART 1308— SCHEDULES OF CONTROLLED SUBSTANCES: Annual Publication" (PDF). Government Publishing Office. Drug Enforcement Administration. Archived from the original (PDF) on September 6, 2023. Retrieved September 6, 2023.
  9. ^ Dhillon, Uttam (January 24, 2020). "Schedules of Controlled Substances: Placement of Brexanolone in Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved September 6, 2023.
  10. ^ a b c d e f g h i j k l m n o p q r s t u Mullen, Jr., Francis M. (October 5, 1984). "Schedules of Controlled Substances; Temporary Placement of Bromazepam, Camazepam, Clobazam, Clotiazepam, Cloxazolam, Delorazepam, Estazolam, Ethyl Loflazepate, Fludiazepam, Flunitrazepam, Haloxazolam, Ketazolam, Loprazolam, Lormetazepam, Medazepam, Nimetazepam, Nitrazepam, Nordiazepam, Oxazolam, Pinazepam, and Tetrazepam Into Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  11. ^ Leonhart, Michele (December 12, 2011). "Schedules of Controlled Substances: Placement of Carisoprodol Into Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  12. ^ a b c d e f Bartels, Jr., John R. (May 28, 1975). "Schedules of Controlled Substances; Placement of Chlordiazepoxide, Diazepam, Oxazepam, Chlorazepate, Flurazepam, and Clonazepam into Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  13. ^ Milgram, Anne (April 7, 2022). "Schedules of Controlled Substances: Placement of Daridorexant in Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  14. ^ Simpkins, William (August 16, 2001). "Schedules of controlled substances: Dichloralphenazone; placement into Schedule IV". VLEX. Drug Enforcement Administration. Archived from the original on January 16, 2023. Retrieved January 16, 2023.
  15. ^ Leonhart, Michele (October 6, 2009). "Schedules of Controlled Substances; Placement of Fospropofol Into Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  16. ^ Mullen, Jr., Francis M. (October 29, 1981). "Schedules of Controlled Substances: Placement of Halazepam in Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  17. ^ Evans, D. Christopher (March 3, 2021). "Schedules of Controlled Substances: Placement of Lemborexant in Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  18. ^ Bensinger, Peter (October 7, 1977). "Placement of Lorazepam in Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  19. ^ Bartels, Jr., John R. (January 30, 1975). "Placement of Mebutamate in Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2022.
  20. ^ a b Lawn, John (March 25, 1986). "Schedules of Controlled Substances; Placement of Quazepam and Midazolam into Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  21. ^ Bensinger, Peter (December 17, 1976). "Placement of Prazepam into Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  22. ^ Evans, D. Christopher (July 2, 2021). "Schedules of Controlled Substances: Placement of Remimazolam in Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved September 6, 2023.
  23. ^ Harrigan, Thomas (August 28, 2014). "Schedules of Controlled Substances: Placement of Suvorexant into Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  24. ^ Bensinger, Peter (April 7, 1981). "Schedules of Controlled Substances; Placement of Temazepam into Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  25. ^ Mullen, Jr., Francis M. (December 28, 1982). "Schedules of Controlled Substances; Placement of Triazolam into Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  26. ^ Marshall, Donnie (September 15, 1999). "Schedules of Controlled Substances; Placement of Zaleplon into Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  27. ^ Bonner, Robert (February 5, 1993). "Schedules of Controlled Substances; Placement of Zolpidem into Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on March 3, 2022. Retrieved January 16, 2023.
  28. ^ Leonhart, Michele (April 4, 2005). "Schedules of Controlled Substances: Placement of Zopiclone Into Schedule IV". Federal Register. Drug Enforcement Administration.
  29. ^ Milgram, Anne (October 31, 2023). "Schedules of Controlled Substances: Placement of Zuranolone in Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved November 3, 2023.
  30. ^ Leonhart, Michele (May 8, 2013). "Schedules of Controlled Substances: Placement of Lorcaserin Into Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  31. ^ a b c d Lawn, John (May 17, 1988). "Schedules of Controlled Substances; Temporary Placement of Cathine ((+ )-norpseudoephedrine), Fencamfamin, Fenproporex and Mefenorex Into Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on March 3, 2022. Retrieved January 16, 2023.
  32. ^ a b Ingersoll, John (July 6, 1973). "Diethylpropion and Phentermine; Temporary Placement in Schedule IV" (PDF). Isomer Design. Bureau of Narcotics and Dangerous Drugs. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  33. ^ Mullen, Jr., Francis M. (October 27, 1981). "Rescheduling of Mazindol into Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on September 26, 2021. Retrieved January 16, 2023.
  34. ^ Marshall, Donnie (January 27, 1999). "Schedules of Controlled Substances: Placement of Modafinil Into Schedule IV". Federal Register. Drug Enforcement Administration.
  35. ^ Bartels, Jr., John R. (January 28, 1975). "Placement of Pemoline in Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  36. ^ a b Bensinger, Peter (September 30, 1980). "Pipradrol and SPA in Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  37. ^ Milgram, Anne (July 25, 2022). "Schedules of Controlled Substances: Placement of Serdexmethylphenidate in Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved September 6, 2023.
  38. ^ Gruden, Peter (February 11, 1998). "Schedules of Controlled Substances: Placement of Sibutramine Into Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  39. ^ Dhillon, Uttam (January 7, 2020). "Schedules of Controlled Substances: Placement of Solriamfetol in Schedule IV". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
  40. ^ Bensinger, Peter (February 9, 1979). "Placement of Pentazocine into Schedule IV" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
  41. ^ Milford, Jr., James S. (October 31, 1997). "Schedules of Controlled Substances Placement of Butorphanol Into Schedule IV". Federal Register. Drug Enforcement Administration. Archived from the original on January 16, 2023. Retrieved January 16, 2023.
  42. ^ Rosenberg, Chuck (November 12, 2015). "Schedules of Controlled Substances: Placement of Eluxadoline Into Schedule IV". Federal Register. Drug Enforcement Administration. Archived from the original on January 16, 2023. Retrieved January 16, 2023.
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