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CEBPG

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CEBPG
Identifiers
AliasesCEBPG, GPE1BP, IG/EBP-1, CCAAT/enhancer binding protein gamma, CCAAT enhancer binding protein gamma
External IDsOMIM: 138972; MGI: 104982; HomoloGene: 1368; GeneCards: CEBPG; OMA:CEBPG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001806
NM_001252296

NM_009884

RefSeq (protein)

NP_001239225
NP_001797

NP_034014

Location (UCSC)Chr 19: 33.37 – 33.38 MbChr 7: 34.75 – 34.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCAAT/enhancer-binding protein gamma (C/EBPγ) is a protein that in humans is encoded by the CEBPG gene.[5][6] This gene has no introns.

The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBPα, C/EBPβ, C/EBPγ, C/EBPδ, C/EBPζ, and C/EBPε, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind the positive regulatory element-I (PRE-I) enhancer elements.[6][7]

C/EBPγ forms heterodimer with ATF4 for transcriptional activation of target genes in autophagy specifically to amino acid starvation.[8]

C/EBPγ along with its regulator, the trauma-induced transcription factor EGR1, plays an important role in the development of chronic pain and mechanical hypersensitivity after some types of injury or surgery.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153879Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056216Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Williams SC, Cantwell CA, Johnson PF (September 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–1567. doi:10.1101/gad.5.9.1553. PMID 1884998.
  6. ^ a b "Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma".
  7. ^ Davydov IV, Bohmann D, Krammer PH, Li-Weber M (August 1995). "Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter". Gene. 161 (2): 271–275. doi:10.1016/0378-1119(95)00271-7. PMID 7665092.
  8. ^ Kim D, Kim J, Yu YS, Kim YR, Baek SH, Won KJ (July 2022). "Systemic approaches using single cell transcriptome reveal that C/EBPγ regulates autophagy under amino acid starved condition". Nucleic Acids Research. 50 (13): 7298–7309. doi:10.1093/nar/gkac593. PMC 9303372. PMID 35801910.
  9. ^ Mamet J, Klukinov M, Yaksh TL, Malkmus SA, Williams S, Harris S, et al. (February 2014). "Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury". Pain. 155 (2): 322–333. doi:10.1016/j.pain.2013.10.015. PMID 24145208. S2CID 29286007.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.