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Revision as of 16:26, 13 March 2024
Sir Tim Hunt | |
---|---|
![]() Hunt at UCSF in 2009 | |
Born | Richard Timothy Hunt 19 February 1943[11] |
Citizenship | United Kingdom |
Education | |
Alma mater | University of Cambridge (BA, PhD) |
Known for | Cell cycle regulation |
Spouse | [11] |
Children | Two daughters[11] |
Awards |
|
Scientific career | |
Fields | Cell cycle[4] (Biochemistry) |
Institutions | |
Thesis | The synthesis of haemoglobin (1969) |
Doctoral advisor | Asher Korner[5] |
Doctoral students |
Sir Richard Timothy Hunt, FRS FMedSci FRSE MAE (born 19 February 1943) is a British biochemist and molecular physiologist. He was awarded the 2001 Nobel Prize in Physiology or Medicine with Paul Nurse and Leland H. Hartwell for their discoveries of protein molecules that control the division of cells. While studying fertilized sea urchin eggs in the early 1980s, Hunt discovered cyclin, a protein that cyclically aggregates and is depleted during cell division cycles.
Early life and education
Hunt was born on 19 February 1943[11] in Neston, Cheshire, to Richard William Hunt, a lecturer in palaeography in Liverpool, and Kit Rowland, daughter of a timber merchant.[12] After the death of both his parents, Hunt found his father had worked at Bush House, then the headquarters of BBC World Service radio, most likely in intelligence, although it is not known what he actually did.[12] In 1945, Richard became Keeper of the Western Manuscripts at the Bodleian Library, and the family relocated to Oxford. At the age of eight, Hunt was accepted into the Dragon School,[11] where he first developed an interest in biology thanks to his German teacher, Gerd Sommerhoff.[12] When he was fourteen, he moved to Magdalen College School, Oxford, where the science prizes now bear his name, becoming even more interested in science and studying subjects such as chemistry and zoology.[12][13][14][15]
In 1961, he was accepted into Clare College, Cambridge to study Natural Sciences, graduating in 1964 and immediately beginning work in the university Department of Biochemistry under Asher Korner.[12] There, he worked with scientists such as Louis Reichardt and Tony Hunter.[12] A 1965 talk by Vernon Ingram interested him in haemoglobin synthesis, and at a Greek conference in 1966 on the subject, he persuaded the haematologist and geneticist Irving London to allow him to work in his laboratory at Albert Einstein College of Medicine in New York, staying from July to October 1966.[12] His PhD was supervised by Asher Korner[5] and focused on haemoglobin synthesis in intact rabbit reticulocytes (immature red blood cells), and was awarded in 1968.[5][16][17]
Career and research
Early career
Following his PhD, Hunt returned to New York to work with London, in collaboration with Nechama Kosower, her husband Edward Kosower, and Ellie Ehrenfeld. While there, they discovered that tiny amounts of glutathione inhibited protein synthesis in reticulocytes and that tiny amounts of RNA killed the synthesis altogether. After returning to Cambridge, he again began work with Tony Hunter and Richard Jackson, who had discovered the RNA strand used to start haemoglobin synthesis. After 3–4 years, the team discovered at least two other chemicals acting as inhibitors.[12]
Hunt regularly spent summers working at the Marine Biological Laboratory at Woods Hole, Massachusetts, which was popular with scientists for its advanced summer courses, and in particular, with those interested in the study of mitosis. The location provided a ready supply of surf clams and sea urchins amongst the reefs and fishing docks, and it was these invertebrates that were particularly useful for the study of the synthesis of proteins in embryogenesis, as the embryos were simply generated with the application of filtered sea water, and the transparency of the embryo cells was well suited to microscopic study.[18]
Discovery of cyclins
It was at Woods Hole in the Summer of 1982, using the sea urchin (Arbacia punctulata) egg as his model organism, that he discovered the cyclin molecule.[12] Hunt was a keen cyclist and named the protein based on his observation of the cyclical changes in its levels.[19]
Cyclins are proteins that play a key role in regulating the cell-division cycle.[20] Hunt found that cyclins begin to be synthesised after the eggs are fertilised and increase in levels during interphase, until they drop very quickly in the middle of mitosis in each cell division. He also found that cyclins are present in vertebrate cells, where they also regulate the cell cycle. He and others subsequently showed that cyclins bind and activate a family of protein kinases, now called the cyclin-dependent kinases, one of which had been identified as a crucial cell cycle regulator by Paul Nurse. The cyclin mechanism of cell division is fundamental to all living organisms (excluding bacteria) and thus the study of the process in simple organisms helps shed light on the growth of tumours in humans.[21]
Later career
![](http://upload.wikimedia.org/wikipedia/commons/thumb/6/61/OIST_BOG_Members_After_Meeting_Prime_Minister_Shinzo_Abe_4_October_2013_20131004.jpg/200px-OIST_BOG_Members_After_Meeting_Prime_Minister_Shinzo_Abe_4_October_2013_20131004.jpg)
In 1990, he began work at Imperial Cancer Research Fund, later known as the Cancer Research UK London Research Institute, in the United Kingdom, where his work focused on understanding on what makes cell go cancerous, that is: proliferate uncontrollably, with the ordinary inhibitory signals switched off.[22] Hunt had his own laboratory at the Clare Hall Laboratories until the end of 2010, and remains an Emeritus Group Leader at the Francis Crick Institute.[21][23] He is a member of the Advisory Council for the Campaign for Science and Engineering.[24] He has served on the Selection Committee for the Shaw Prize in Life Science and Medicine.[25] In 2010, Hunt joined the Academic Advisory Board of the Austrian think tank Academia Superior, Institute for Future Studies.[26]
Hunt is a highly regarded colleague and mentor in the research community.[27][28] During his career he has supervised numerous PhD students including Hugh Pelham[6] and Jonathon Pines.[8]
Science advocacy
In addition to his scientific contributions, Hunt is a lifelong advocate for scientific research. After winning the Nobel Prize in 2001, he spent much of his time traveling the world, talking to both popular and specialist audiences. In these talks he offered his characteristic perspective on inquiry, which emphasizes the importance of having fun and being lucky.[29] He also believes that science benefits when power is given to young people.[30]
Controversy
![]() | The neutrality of this section is disputed. |
In 2015, the Nobel laureate Sir Tim Hunt was involved in a highly publicized controversy at the World Conference of Science Journalists (WCSJ) in Seoul. At a lunch for female journalists and scientists, Hunt gave a speech at short notice which was later recounted by an unnamed EU official:[31][32]
It's strange that such a chauvinist monster like me has been asked to speak to women scientists. Let me tell you about my trouble with girls. Three things happen when they are in the lab: you fall in love with them, they fall in love with you, and when you criticise them they cry. Perhaps we should make separate labs for boys and girls? Now, seriously, I'm impressed by the economic development of Korea. And women scientists played, without a doubt, an important role in it. Science needs women, and you should do science, despite all the obstacles, and despite monsters like me.
These remarks were widely interpreted as sexist, and led to what has been called an online shaming campaign against him.[33][34][35][36] The controversy led to his resignation from several key research and policy positions, including the European Research Council, and a temporary withdrawal from public life and professional activities.[37]
Awards and honours
Hunt was elected a member of the European Molecular Biology Organization (EMBO) in 1978, serving as a member of the organisation's Fellowship Committee 1990–1993, its Meeting Committee 2008–2009, and its governing body, the Council, 2004–2009.[1] He was elected a Fellow of the Royal Society (FRS) in 1991,[2] his certificate of election reads:[38]
Distinguished for his studies of the control of protein synthesis in animal cells and for the discovery of cyclin, a protein which regulates the eukaryotic cell cycle. Together with Jackson and their students, he defined steps in formation of the initiation complex in protein synthesis, showing that the 40S ribosomal subunit binds initiator tRNA before it binds mRNA, and that this step was the target of inhibitors such as double-stranded RNA or haem deficiency. They showed that inhibition of protein synthesis is mediated by reversible phosphorylation of initiation factor eIF-2 by two distinct protein kinases and they elucidated the unexpected roles of thioredoxin and thioredoxin reductase in protein synthesis. With Ruderman and Rosenthal, he demonstrated selective translational control of mRNA in early clam embryos. This led to Hunt's discovery of cyclin as a protein which is selectively destroyed in mitosis. He subsequently cloned and sequenced cyclin cDNA from sea urchins and frogs and showed by elegant mRNA ablation experiments that cyclin translation is necessary for mitosis in frog embryos. He has also shown that cyclin is a subunit of the mitosis-promoting factor which regulates entry into mitosis. His discovery and characterization of cyclin are major contributions to our knowledge of cell cycle regulation in eukaryotic cells.
Hunt was elected a fellow of the UK's Academy of Medical Sciences (FMedSci) in 1998,[39] and a foreign associate of the US National Academy of Sciences in 1999.[40]
In 2001, he was awarded the Nobel Prize in Physiology or Medicine with Leland Hartwell and Paul Nurse for their discoveries regarding cell cycle regulation by cyclin and cyclin-dependent kinases. The three laureates are cited "for their discoveries of key regulators of the cell cycle," while Hunt in particular
is awarded for his discovery of cyclins, proteins that regulate the CDK function. He showed that cyclins are degraded periodically at each cell division, a mechanism proved to be of general importance for cell cycle control.[41]
In 2003, Hunt was made an honorary Fellow of the Royal Society of Edinburgh (HonFRSE).[3] In 2006, he was awarded the Royal Society's Royal Medal, two of which are presented annually for "the most important contributions to the advancement of natural knowledge", in his case for "discovering a key aspect of cell cycle control, the protein cyclin which is a component of cyclin dependent kinases, demonstrating his ability to grasp the significance of the result outside his immediate sphere of interest".[42]
Hunt was knighted in the 2006 Birthday Honours for his service to science.[43]
Personal life
Hunt is married to the immunologist Mary Collins, who was provost of the Okinawa Institute of Science and Technology in Japan, and is now Director of the Blizard Institute Queen Mary University of London. The couple have two daughters.[11]
Selected publications
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- Mochida, Satoru; Maslen, Sarah L; Skehel, Mark; Hunt, Tim (2010). "Greatwall phosphorylates an inhibitor of protein phosphatase 2Α that is essential for mitosis". Science. 330 (6011): 1670–1673. Bibcode:2010Sci...330.1670M. doi:10.1126/science.1195689. PMID 21164013. S2CID 11473305.
- Mochida, Satoru; Hunt, Tim (2007). "Calcineurin is required to release Xenopus egg extracts from meiotic M phase". Nature. 449 (7160): 336–340. Bibcode:2007Natur.449..336M. doi:10.1038/nature06121. PMID 17882219.
- Rouse, John; Cohen, Philip; Trigon, Sylviane; Morange, Michel; Alonso-Llamazares, Ana; Zamanillo, Daniel; Hunt, Tim; Nebreda, Angel R. (1994). "A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins". Cell. 78 (6): 1027–1037. doi:10.1016/0092-8674(94)90277-1. ISSN 0092-8674. PMID 7923353. S2CID 19895515.
- Evans, Tom; Rosenthal, Eric T.; Youngblom, Jim; Distel, Dan; Hunt, Tim (1983). "Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division". Cell. 33 (2): 389–396. doi:10.1016/0092-8674(83)90420-8. ISSN 0092-8674. PMID 6134587.
- Farrell, Paul J.; Balkow, Ken; Hunt, Tim; Jackson, Richard J.; Trachsel, Hans (1977). "Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis". Cell. 11 (1): 187–200. doi:10.1016/0092-8674(77)90330-0. ISSN 0092-8674. PMID 559547. S2CID 20514410.
- Poon, R. Y.; Yamashita, K.; Adamczewski, J. P.; Hunt, T.; Shuttleworth, J. (1993). "The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2". EMBO Journal. 12 (8): 3123–3132. doi:10.1002/j.1460-2075.1993.tb05981.x. PMC 413578. PMID 8393783.
- Nebreda, A.R.; Hunt, T. (1993). "The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs". EMBO J. 12 (5): 1979–1986. doi:10.1002/j.1460-2075.1993.tb05847.x. PMC 413419. PMID 8387916.
- Craig, D.; Howell, M.T.; Gibbs, C.L.; Hunt, T.; Jackson, R.J. (1992). "Plasmid cDNA-directed protein synthesis in a couple eukaryotic in vitro transcription-translation system". Nucleic Acids Res. 20 (19): 4987–4995. doi:10.1093/nar/20.19.4987. PMC 334274. PMID 1383935.
- Standart, N.; Dale, M.; Stewart, E.; Hunt, T. (1990). "Maternal mRNA from clam oocytes can be specifically unmasked in vitro by antisense RNA complementary to the 3' untranslated region". Genes Dev. 4 (12a): 2157–2168. doi:10.1101/gad.4.12a.2157. PMID 2148535.
- Gautier, J.; Minshull, J.; Lohka, M.; Glotzer, M.; Hunt, T.; Maller, J.L. (1990). "Cyclin is a component of MPF from Xenopus". Cell. 60 (3): 487–494. doi:10.1016/0092-8674(90)90599-a. PMID 1967981. S2CID 744044.
- Standart, N.; Minshull, J.; Pines, J.; Hunt, T. (1987). "Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte". Dev. Biol. 124 (1): 248–258. doi:10.1016/0012-1606(87)90476-3. PMID 15669148.
- Minshull, J.; Hunt, T. (1986). "The use of single-stranded DNA and RNase H to promote quantitative 'hybrid arrest of translation' of mRNA/DNA hybrids in reticulocyte lysate cell-free translations". Nucleic Acids Res. 14 (16): 6433–6451. doi:10.1093/nar/14.16.6433. PMC 311656. PMID 3018671.
- Hunt, T.; Herbert, P.; Campbell, E.A.; Delidakis, C.; Jackson, R.J. (1983). "The use of affinity chromatography on 2'-5'ADP- Sepharose reveals a requirement for NADPH, thioredoxin and thioredoxin reductase for the maintenance of high protein synthesis activity in rabbit reticulocyte lysates". Eur. J. Biochem. 131 (2): 303–311. doi:10.1111/j.1432-1033.1983.tb07263.x. PMID 6299735.
- Rosenthal, E.T.; Hunt, T.; Ruderman, J.V. (1980). "Selective translation of mRNA controls the pattern of protein synthesis during early development of the surf clam, Spisula solidissima". Cell. 20 (2): 487–494. doi:10.1016/0092-8674(80)90635-2. PMID 7190072. S2CID 8632207.
- Hunter, A.R.; Hunt, T.; Knowland, J.S.; Zimmern, D. (1976). "Messenger RNA for the coat protein of tobacco mosaic virus". Nature. 260 (5554): 759–764. Bibcode:1976Natur.260..759H. doi:10.1038/260759a0. PMID 1264250. S2CID 4200275.
- Darnbrough, C.H.; Legon, S.; Hunt, T.; Jackson, R.J. (1973). "Initiation of protein synthesis: evidence for messenger RNA- independent binding of methionyl transfer RNA to the 40S ribosomal subunit". J. Mol. Biol. 76 (3): 379–403. doi:10.1016/0022-2836(73)90511-1. PMID 4732074.
- Kosower, N.S.; Vanderhoff, G.A.; Benerofe, B.; Hunt, T.; Kosower, E.M. (1971). "Inhibition of protein synthesis by glutathione disulfide in the presence of glutathione". Biochem. Biophys. Res. Commun. 45 (3): 816–821. doi:10.1016/0006-291x(71)90490-6. PMID 5128185.
- Ehrenfeld, E.; Hunt, T. (1971). "Double-stranded poliovirus RNA inhibits initiation of protein synthesis by reticulocyte lysates". Proc. Natl. Acad. Sci. USA. 68 (5): 1075–1078. Bibcode:1971PNAS...68.1075E. doi:10.1073/pnas.68.5.1075. PMC 389116. PMID 4325000.
- Hunt, T.; Hunter, A.R.; Munro, A.J. (1968). "Control of haemoglobin synthesis: distribution of ribosomes on the messenger RNA for a and b chains". J. Mol. Biol. 36 (1): 31–45. doi:10.1016/0022-2836(68)90217-9. PMID 5760537.
- Murray, Andrew; Hunt, Tim (1993). The Cell Cycle: An Introduction. Oxford: Oxford University Press. ISBN 978-0195095296.
- Wilson, John; Hunt, Tim (2014). Molecular Biology of the Cell: The Problems Book (6th ed.). Taylor & Francis Ltd. ISBN 978-0815344537.
References
- ^ a b "Tim Hunt". Heidelberg: European Molecular Biology Organization.
- ^ a b Anon (1991). "Sir Tim Hunt FMedSci FRS". London: Royal Society. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.
{{cite web}}
: CS1 maint: bot: original URL status unknown (link) - ^ a b "PDF List of Fellows on the webpages of the RSE" (PDF). 24 November 2015. Archived from the original (PDF) on 30 March 2016. Retrieved 28 December 2015.
- ^ Tim Hunt publications indexed by Google Scholar
- ^ a b c Hunt, Richard Timothy (1969). The synthesis of haemoglobin (PhD thesis). University of Cambridge. OCLC 885437139. EThOS uk.bl.ethos.604802.
- ^ a b Pelham, Hugh R. B. (1978). Transcription and Translation in Reticulocyte Lysates. lib.cam.ac.uk (PhD thesis). University of Cambridge. OCLC 500538683. EThOS uk.bl.ethos.468626.
- ^ "Sir Hugh Pelham FMedSci FRS". London: Royal Society. Archived from the original on 17 November 2015.
- ^ a b Pines, Jonathon Noe Joseph (1987). Cyclin : a major maternal message in sea urchin eggs. lib.cam.ac.uk (PhD thesis). University of Cambridge. OCLC 499166627. EThOS uk.bl.ethos.233321.
- ^ Pines, Jonathon; Hunt, Tim (1987). "Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs". The EMBO Journal. 6 (10): 2987–2995. doi:10.1002/j.1460-2075.1987.tb02604.x. PMC 553735. PMID 2826125.
- ^ "Dr Jonathon Pines: Department of Zoology". Cambridge: cam.ac.uk. Archived from the original on 15 May 2015.
- ^ a b c d e f "HUNT, Sir Tim". Who's Who. Vol. 2015 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.) [better source needed]
- ^ a b c d e f g h i "Tim Hunt – Autobiography". Nobelprize.org. Nobel Media AB. 2001. Retrieved 13 November 2008.
- ^ Hunt, Tim (8 August 2015). "Pursuing the impossible: an interview with Tim Hunt". BMC Biology. 13: 64. doi:10.1186/s12915-015-0164-y. PMC 4528683. PMID 26253553.
- ^ Creative Breakthroughs | Tim Hunt | TEDxLancasterU
- ^ BBC Radio 4 interview with Jim Al-Khalili on The Life Scientific
- ^ Hunt, Tim; Hunter, Tony; Munro, Alan (1968). "Control of haemoglobin synthesis: Distribution of ribosomes on the messenger RNA for α and β chains". Journal of Molecular Biology. 36 (1): 31–45. doi:10.1016/0022-2836(68)90217-9. PMID 5760537.
- ^ Hunt, Tim; Hunter, Tony; Munro, Alan (1968). "Control of haemoglobin synthesis: a difference in the size of the polysomes making alpha and beta chains". Nature. 220 (5166): 481–483. Bibcode:1968Natur.220..481H. doi:10.1038/220481a0. PMID 5686164. S2CID 4293819.
- ^ Jackson, Peter K. (July 2008). "The Hunt for Cyclin". Cell. 134 (2): 199–202. doi:10.1016/j.cell.2008.07.011. PMID 18662532. S2CID 1974575.
- ^ "Understanding how cells divide – the story of a Nobel prize". Cancer Research UK – Science blog. 6 October 2014. Retrieved 24 October 2015.
- ^ "The Nobel Prize in Physiology or Medicine 2001". Nobel Prize Outreach. Retrieved 8 August 2022.
- ^ a b "Cancer Research UK: Tim Hunt". Archived from the original on 13 October 2008. Retrieved 13 November 2008.
- ^ Liz Hunt (21 December 2010). "Sir Tim Hunt: I am interested in how cells know what they are and how they should behave (Interview)". The Telegraph. Retrieved 26 December 2015.
- ^ "Tim Hunt biography on the web pages of the Francis Crick Institute". Archived from the original on 15 April 2019. Retrieved 15 April 2019.
- ^ "Advisory Council of the Campaign for Science and Engineering". Archived from the original on 28 August 2010. Retrieved 11 February 2011.
- ^ "Shaw Prize Website: Selection Committee". Archived from the original on 26 December 2015. Retrieved 25 December 2015.
- ^ Academia Superior – Academic Advisory Board. Retrieved 30 March 2019.
- ^ "Tim Hunt plaudits (Letter to the editor)". The Times. 23 June 2015. Retrieved 28 December 2015.
- ^ Whipple, T. (23 June 2015). "Women scientists defend 'sexist' Nobel winner". The Times. Retrieved 28 December 2015.
- ^ "I admire people who do fun things" on YouTube
- ^ Torres, Isabel (April 2014). "I Believe in Giving Power to the Young". Labtimes. Freiburg: LJ-Verlag. Archived from the original on 16 March 2019. Retrieved 13 April 2019.
- ^ Saul, Heather (24 June 2015). "Richard Dawkins demands apology from Sir Tim Hunt's critics and claims leaked transcript shows 'sexist' comments were 'light-hearted banter'". The Independent. London. Archived from the original on 24 May 2022. Retrieved 24 June 2015.
- ^ Radcliffe, Rebecca (10 June 2015). "Nobel scientist Tim Hunt: female scientists cause trouble for men in labs". The Guardian. Retrieved 10 June 2015.
- ^ McKie, Robin (13 June 2015). "Tim Hunt: 'I've been hung out to dry. They haven't even bothered to ask for my side of affairs'". The Observer. Retrieved 14 June 2015.
- ^ Billingham, Paul; Parr, Tom (2020). "Enforcing social norms: The morality of public shaming". European Journal of Philosophy. 28 (4). doi:10.1111/ejop.12543.
- ^ Aitchison, Guy; Meckled-Garcia, Saladin (2021). "Against Online Public Shaming: Ethical Problems with Mass Social Media". Social Theory and Practice. 47 (1).
- ^ Adkins, Karen (2019). "When Shaming Is Shameful: Double Standards in Online Shame Backlashes". Hypatia. 34 (1). doi:10.1111/hypa.12456.
- ^ Robin McKie (19 December 2015). "Tim Hunt and Mary Collins: 'We're not being chased out of the country. Our new life's an adventure'". The Guardian. Retrieved 28 December 2015.
- ^ "Certificate of election EC/1991/14: Hunt, Richard Timothy". London: Royal Society. Archived from the original on 5 December 2018.
- ^ "Fellow list entry for Tim Hunt on the Academy web pages". Archived from the original on 4 December 2018. Retrieved 28 December 2015.
- ^ "Tim Hunt entry in the online member directory of the US National Academy of Sciences". Retrieved 26 December 2015.
- ^ "The Nobel Prize in Physiology or Medicine 2001". nobelprize.org.
- ^ "Royal Medal recent winners". Retrieved 13 November 2008.
- ^ Recorded in The Gazette (London Gazette), issue 58014, 16 June 2006, supplement 1. [1]
External links
- Since winning the Nobel Prize in Physiology or Medicine in 2001, Hunt has lectured regularly about the joys of scientific discovery.
- At the 2010 Lindau Meeting, Hunt participated in a Nature video about systems biology.
- In July 2015, the historian/anthropologist Alan Macfarlane conducted two in-depth interviews with Tim Hunt:
- Tim Hunt on Nobelprize.org including the Nobel Lecture 9 December 2001 Protein Synthesis, Proteolysis, and Cell Cycle Transitions
- Tim Hunt publications indexed by Google Scholar
Media related to Tim Hunt at Wikimedia Commons
- 1943 births
- Living people
- People from Neston
- People educated at The Dragon School
- People educated at Magdalen College School, Oxford
- Alumni of Clare College, Cambridge
- Fellows of Clare College, Cambridge
- English biochemists
- English biologists
- Members of the European Molecular Biology Organization
- Fellows of the Royal Society
- Royal Medal winners
- Knights Bachelor
- English Nobel laureates
- British Nobel laureates
- Nobel laureates in Physiology or Medicine
- Foreign associates of the National Academy of Sciences
- Fellows of the Academy of Medical Sciences (United Kingdom)
- Academics of the Francis Crick Institute