MAPKAP1

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene. As the name indicates, it is a subunit of mTOR complex 2.

MAPKAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VOQ
Identifiers
Aliases	MAPKAP1, JC310, MIP1, SIN1, SIN1b, SIN1g, mitogen-activated protein kinase associated protein 1, MAPK associated protein 1
External IDs	OMIM: 610558; MGI: 2444554; HomoloGene: 11473; GeneCards: MAPKAP1; OMA:MAPKAP1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q33.3 Start 125,437,393 bp End 125,707,234 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 B Start 34,406,771 bp End 34,624,950 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh apex of heart stromal cell of endometrium oocyte gastrocnemius muscle secondary oocyte right auricle left adrenal cortex left ventricle right adrenal cortex Top expressed in zygote genital tubercle secondary oocyte tail of embryo spermatocyte muscle of thigh ventricular zone interventricular septum epithelium of lens spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol-3,4-bisphosphate binding phosphatidic acid binding protein binding phosphatidylinositol-4,5-bisphosphate binding protein kinase binding phosphatidylinositol-3,4,5-trisphosphate binding Cellular component Golgi apparatus membrane plasma membrane nucleoplasm cytoplasmic vesicle nucleus cytosol TORC2 complex cytoplasm Biological process substantia nigra development negative regulation of Ras protein signal transduction establishment or maintenance of actin cytoskeleton polarity stress-activated protein kinase signaling cascade TORC2 signaling activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation regulation of cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79109 227743 Ensembl ENSG00000119487 ENSMUSG00000038696 UniProt Q9BPZ7 Q8BKH7 RefSeq (mRNA) NM_001006617 NM_001006618 NM_001006619 NM_001006620 NM_001006621 NM_024117 NM_001290625 NM_001290626 NM_177345 NM_001362919 NM_001362920 NM_001362921 RefSeq (protein) NP_001006618 NP_001006619 NP_001006620 NP_001006621 NP_001006622 NP_077022 NP_001277554 NP_001277555 NP_796319 NP_001349848 NP_001349849 NP_001349850 Location (UCSC) Chr 9: 125.44 – 125.71 Mb Chr 2: 34.41 – 34.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.

Further reading

• Colicelli J, Nicolette C, Birchmeier C, et al. (1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2913–7. Bibcode:1991PNAS...88.2913C. doi:10.1073/pnas.88.7.2913. PMC 51350. PMID 1849280.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Schroder W, Bushell G, Sculley T (2005). "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins". Cell. Signal. 17 (6): 761–7. doi:10.1016/j.cellsig.2004.10.015. PMID 15722200.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Cheng J, Zhang D, Kim K, et al. (2005). "Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation". Mol. Cell. Biol. 25 (14): 5955–64. doi:10.1128/MCB.25.14.5955-5964.2005. PMC 1168836. PMID 15988011.
• Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Frias MA, Thoreen CC, Jaffe JD, et al. (2006). "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s". Curr. Biol. 16 (18): 1865–70. Bibcode:2006CBio...16.1865F. doi:10.1016/j.cub.2006.08.001. PMID 16919458. S2CID 8239162.
• Jacinto E, Facchinetti V, Liu D, et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell. 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. PMID 16962653. S2CID 230319.
• Yang Q, Inoki K, Ikenoue T, et al. (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes Dev. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC 1619946. PMID 17043309.
• Makino C, Sano Y, Shinagawa T, et al. (2007). "Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway". Genes Cells. 11 (11): 1239–51. doi:10.1111/j.1365-2443.2006.01016.x. PMID 17054722. S2CID 10605647.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Schroder WA, Buck M, Cloonan N, et al. (2007). "Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling". Cell. Signal. 19 (6): 1279–89. doi:10.1016/j.cellsig.2007.01.013. PMID 17303383.