Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.[5][6][7][8]

KRT34
Identifiers
AliasesKRT34, HA4, Ha-4, KRTHA4, hHa4, Keratin 34, K34
External IDsOMIM: 602763; MGI: 1309994; HomoloGene: 31083; GeneCards: KRT34; OMA:KRT34 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021013
NM_001386014

NM_027563

RefSeq (protein)

NP_066293

NP_081839

Location (UCSC)Chr 17: 41.38 – 41.38 MbChr 11: 99.93 – 99.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.[8]

See also

edit

References

edit
  1. ^ a b c ENSG00000262045 GRCh38: Ensembl release 89: ENSG00000131737, ENSG00000262045Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043485Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Heid HW, Werner E, Franke WW (Feb 1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins". Differentiation. 32 (2): 101–19. doi:10.1111/j.1432-0436.1986.tb00562.x. PMID 2431943.
  6. ^ Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
  7. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  8. ^ a b "Entrez Gene: KRT34 keratin 34".

Further reading

edit