FGF12

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.

FGF12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q1U, 4JQ0
Identifiers
Aliases	FGF12, FGF12B, FHF1, fibroblast growth factor 12, EIEE47, DEE47
External IDs	OMIM: 601513; MGI: 109183; HomoloGene: 10874; GeneCards: FGF12; OMA:FGF12 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q28-q29 Start 192,139,390 bp End 192,767,764 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 B2|16 19.38 cM Start 27,978,850 bp End 28,571,820 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right auricle cardiac muscle tissue of right atrium apex of heart pons myocardium of left ventricle right ventricle right adrenal cortex left adrenal cortex middle temporal gyrus prefrontal cortex Top expressed in superior frontal gyrus medial dorsal nucleus facial motor nucleus dentate gyrus of hippocampal formation granule cell medial geniculate nucleus pontine nuclei anterior horn of spinal cord lateral septal nucleus lateral geniculate nucleus medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sodium channel regulator activity heparin binding transmembrane transporter binding fibroblast growth factor receptor binding protein binding growth factor activity Cellular component nucleus intracellular anatomical structure extracellular space Biological process negative regulation of cation channel activity adult locomotory behavior cell-cell signaling cardiac muscle cell action potential involved in contraction regulation of membrane depolarization nervous system development fibroblast growth factor receptor signaling pathway JNK cascade heart development neuromuscular process regulation of sodium ion transmembrane transporter activity positive regulation of sodium ion transport regulation of sodium ion transmembrane transport signal transduction chemical synaptic transmission regulation of voltage-gated sodium channel activity regulation of neuronal action potential regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2257 14167 Ensembl ENSG00000114279 ENSMUSG00000022523 UniProt P61328 P61329 RefSeq (mRNA) NM_004113 NM_021032 NM_001377292 NM_001377293 NM_001377294 NM_001276419 NM_001276420 NM_010199 NM_183064 NM_001357064 RefSeq (protein) NP_004104 NP_066360 NP_001364221 NP_001364222 NP_001364223 NP_001263348 NP_001263349 NP_034329 NP_898887 NP_001343993 Location (UCSC) Chr 3: 192.14 – 192.77 Mb Chr 16: 27.98 – 28.57 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Kok LD, Tsui SK, Waye M, et al. (1999). "Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart". Biochem. Biophys. Res. Commun. 255 (3): 717–21. doi:10.1006/bbrc.1999.0178. PMID 10049777.
• Schoorlemmer J, Goldfarb M (2001). "Fibroblast growth factor homologous factors are intracellular signaling proteins". Curr. Biol. 11 (10): 793–7. Bibcode:2001CBio...11..793S. doi:10.1016/S0960-9822(01)00232-9. PMC 3216481. PMID 11378392.
• Liu CJ, Dib-Hajj SD, Renganathan M, et al. (2003). "Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B". J. Biol. Chem. 278 (2): 1029–36. doi:10.1074/jbc.M207074200. PMID 12401812.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Olsen SK, Garbi M, Zampieri N, et al. (2003). "Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs". J. Biol. Chem. 278 (36): 34226–36. doi:10.1074/jbc.M303183200. PMID 12815063.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J. Biol. Chem. 279 (38): 40146–52. doi:10.1074/jbc.M405795200. PMID 15199049.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.