ANTITUMOR ACTIVITY IN MICE OF ORALLY ADMINISTERED POLYSACCHARIDE FROM KEFIR GRAIN
1982 Volume 35 Issue 2 Pages 75-80
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1982 Volume 35 Issue 2 Pages 75-80
The antitumor activity of a water-soluble polysaccharide (KGF-C), isolated from the Kefir grain, was studied in the mice subcutaneously inoculated with Ehrich carcinoma (EC) or Sarcoma 180 (S-180) . The growth of EC and S-180 solid tumor was inhibited by 40-59% and 21-81%, respectively, by oral administration of KGF-C as compared with the unadministered mice. The tumor growth was similarly inhibited by intraperitoneal administration. The mechanism of the antitumor activity of KGF-C was considered to be host-mediated because of the lack of direct in vitro effect on tumor cells.
