TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities
Abstract
:1. Introduction
2. Current Diagnostic Imaging and Therapy of TNBC
3. SELEX Technology
4. Cell-SELEX against TNBC Cells to Generate Cell-Type Targeting Aptamers
5. Aptamers Targeting Proteins Overexpressed on TNBC Cells
5.1. Aptamer Targeting EGFR and PDGFRβ Receptor Tyrosine Kinases
5.2. Mucin 1
5.3. Nucleolin
6. Aptamers Targeting Surface Markers of Cancer stem Cells to Address TNBC Chemoresistance
7. Aptamers Targeting the Tumor Microenvironment in TNBC
7.1. Mesenchymal Stem Cells
7.2. Vascular Endothelial Cells
7.3. Immune Cells
7.4. Extracellular Matrix
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Camorani, S.; Fedele, M.; Zannetti, A.; Cerchia, L. TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities. Pharmaceuticals 2018, 11, 123. https://doi.org/10.3390/ph11040123
Camorani S, Fedele M, Zannetti A, Cerchia L. TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities. Pharmaceuticals. 2018; 11(4):123. https://doi.org/10.3390/ph11040123
Chicago/Turabian StyleCamorani, Simona, Monica Fedele, Antonella Zannetti, and Laura Cerchia. 2018. "TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities" Pharmaceuticals 11, no. 4: 123. https://doi.org/10.3390/ph11040123