Healthy Eating beyond Whole Grains—Insight on Associations between Diet Quality and Arterial Stiffness in the Brisighella Heart Study Cohort
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Participants and Design
Inclusion and Exclusion Criteria
2.2. Covariate Ascertainment
2.2.1. Clinical Assessment
2.2.2. Hemodynamic Evaluation
2.2.3. Laboratory Assessment
2.3. Statistical Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameters | Men (Mean ± SD) | Women (Mean ± SD) | p-Value |
---|---|---|---|
Age (years) | 58.2 ± 15.6 | 58.2 ± 15.8 | 0.977 |
Waist Circumference (cm) | 97.1 ± 11.3 | 87.9 ± 13.5 | <0.001 |
Hip Circumference (cm) | 100.9 ± 11.8 | 100.4 ± 3.2 | 0.468 |
BMI (kg/m2) | 27.1 ± 3.9 | 26.3 ± 5.1 | <0.001 |
Waist/Hip Ratio | 0.95 ± 0.09 | 0.87 ± 0.09 | <0.001 |
Index of Central Obesity | 0.56 ± 0.07 | 0.56 ± 0.09 | 0.120 |
Heart Rate (bpm) | 61.5 ± 11.4 | 66.3 ± 11.3 | <0.001 |
SBP (mmHg) | 140.8 ± 8.6 | 141.2 ± 12.8 | 0.705 |
DBP (mmHg) | 75.4 ± 4.7 | 71.8 ± 4.5 | <0.001 |
Pulse Pressure (mmHg) | 65.4 ± 7.3 | 69.3 ± 9.7 | <0.001 |
MAP (mmHg) | 97.2 ± 11.5 | 94.9 ± 12.5 | <0.001 |
Pulse Pressure Index | 0.46 ± 0.06 | 0.48 ± 0.06 | <0.001 |
Aortic BP (mmHg) | 137.5 ± 8.6 | 138.3 ± 12.8 | 0.459 |
Aortic PP (mmHg) | 62.1 ± 7.2 | 66.5 ± 9.6 | <0.001 |
Augmentation Index | 24.3 ± 8.8 | 26.7 ± 8.9 | <0.001 |
Pulse Wave Velocity (m/s) | 9.2 ± 2.2 | 9.1 ± 2.5 | 0.441 |
Parameters | Men (Mean ± SD) | Women (Mean ± SD) | p-Value |
---|---|---|---|
TC (mg/dL) | 210.7 ± 40 | 220.2 ± 39.7 | <0.001 |
TG (mg/dL) | 126.8 ± 79.2 | 111.1 ± 60.2 | <0.001 |
HDL-C (mg/dL) | 48 ± 13.9 | 55.1 ± 15.6 | <0.001 |
LDL-C (mg/dL) | 137.8 ± 36.4 | 143 ± 37.1 | 0.006 |
Lp(a) (mg/dL) | 20.1 ± 27.9 | 22.9 ± 30 | 0.021 |
Apo B (mg/dL) | 90.3 ± 18.7 | 92.0 ± 21.9 | 0.099 |
Apo AI (mg/dL) | 145.6 ± 24.1 | 160.8 ± 29.3 | <0.001 |
LDL-C/Apo B | 1.53 ± 0.31 | 1.57 ± 0.32 | 0.016 |
HDL-C/Apo AI | 0.32 ± 0.06 | 0.34 ± 0.06 | 0.062 |
Fasting glucose (mg/dL) | 98.2 ± 11 | 93.0 ± 17.9 | <0.001 |
AST (U/L) | 24.9 ± 8.7 | 22.2 ± 12 | 0.002 |
ALT (U/L) | 28.6 ± 6.7 | 20.8 ± 11 | <0.001 |
Gamma-GT (U/L) | 33.6 ± 11.1 | 21.3 ± 12.8 | <0.001 |
SUA (mg/dL) | 5.9 ± 1.1 | 4.6 ± 1.2 | <0.001 |
Creatinine (mg/dL) | 1.14 ± 0.17 | 0.95 ± 0.16 | <0.001 |
eGFR (mL/min) | 72.7 ± 15.1 | 69 ± 15.7 | <0.001 |
CPK (U/L) | 147.1 ± 87.1 | 113.3 ± 72.8 | <0.001 |
Sex | Predictors | Direction of the Prediction | B | 95% Confidence Interval | p-Value | |
---|---|---|---|---|---|---|
Lower Limit | Upper Limit | |||||
Men | eGFR | −0.148 | −0.259 | −0.038 | <0.001 | |
SUA | 0.220 | 0.095 | 0.320 | 0.001 | ||
sHEI | −0.231 | −0.327 | −0.089 | <0.001 | ||
Women | BMI | 0.174 | 0.111 | 0.331 | 0.002 | |
eGFR | −0.152 | −0.266 | −0.052 | <0.001 | ||
SUA | 0.278 | 0.158 | 0.354 | <0.001 | ||
sHEI | −0.218 | −0.308 | −0.115 | <0.001 |
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Giovannini, M.; Fogacci, F.; D’Addato, S.; Grandi, E.; Borghi, C.; Cicero, A.F.G., on behalf of the Brisighella Heart Study Group. Healthy Eating beyond Whole Grains—Insight on Associations between Diet Quality and Arterial Stiffness in the Brisighella Heart Study Cohort. Nutrients 2024, 16, 2792. https://doi.org/10.3390/nu16162792
Giovannini M, Fogacci F, D’Addato S, Grandi E, Borghi C, Cicero AFG on behalf of the Brisighella Heart Study Group. Healthy Eating beyond Whole Grains—Insight on Associations between Diet Quality and Arterial Stiffness in the Brisighella Heart Study Cohort. Nutrients. 2024; 16(16):2792. https://doi.org/10.3390/nu16162792
Chicago/Turabian StyleGiovannini, Marina, Federica Fogacci, Sergio D’Addato, Elisa Grandi, Claudio Borghi, and Arrigo F. G. Cicero on behalf of the Brisighella Heart Study Group. 2024. "Healthy Eating beyond Whole Grains—Insight on Associations between Diet Quality and Arterial Stiffness in the Brisighella Heart Study Cohort" Nutrients 16, no. 16: 2792. https://doi.org/10.3390/nu16162792