Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans
Abstract
:1. Introduction
2. Results and Discussion
2.1. Structural Elucidation of New Compounds
No. | 1 | 2 | 3 | 4 |
---|---|---|---|---|
2 | 5.26 d (11.5) | 5.28 d (9.5) | 5.09 d (10.4) | 5.50 d (10.0) |
3 | 3.11 brd (11.5) | 2.64 dd (9.5,10.5) | 2.77 dd (10.4,10.4) | 5.00 d (10.0) |
5 | 1.55 m | 1.76 m | 1.85 m | 2.16 m |
1.74 m | 1.78 m | 1.80 m | 2.20 m | |
6 | 1.68 m | 1.35 m | 1.70 m | 1.43 m |
1.74 m | 1.74 m | 1.82 m | 1.96 m | |
7 | 1.90 m | 1.97 ddd (8.5,10.0,10.5) | 2.50 m | 3.02 brd (10.0) |
9 | 1.90 m | 1.62 ddd (3.0,5.0,14.0) | 2.25 m | 1.48 m |
1.92 m | 1.82 brdd (10.0,14.0) | 2.20 m | 1.46 m | |
10 | 2.00 m | 2.05 m | 2.45 m | 1.34 m |
2.02 m | 2.41 ddd (8.0, 10.0, 12.0) | 1.40 m | 1.67 m | |
11 | 5.49 dd (3.0,5.0) | 5.36 dd (4.5, 8.0) | 2.88 dd (4.2, 9.8) | 3.14 d (8.5) |
13 | 2.00 dd (9.0,11.5) | 2.09 dd (11.5, 13.0) | 2.13 d (13.3) | 1.48 m |
2.62 brd (11.5) | 2.50 dd (3.0, 13.0) | 1.50 dd (10.7, 13.3) | 1.73 m | |
14 | 5.04 brd (9.0) | 4.86 dd (3.0, 11.5) | 3.83 d (10.7) | 1.93 m |
2.45 m | ||||
15 | 2.68 qq (7.0, 7.0) | 2.56 qq (7.0, 7.0) | 2.49 qq (6.8, 6.8) | |
16 | 1.12 d (7.0) | 1.09 d (7.0) | 1.03 d (6.9) | |
17 | 1.13 d (7.0) | 1.15 d (7.0) | 1.14 d (6.9) | 1.73 s |
18 | 1.19 s | 1.11 s | 1.17 s | 1.78 s |
19 | 1.23 s | 1.15 s | 4.96 brs | 0.98 s |
4.91 brs | ||||
20 | 1.60 s | 1.73 s | 1.49 s | 0.98 s |
No. | 1 | 2 | 3 | 4 |
---|---|---|---|---|
1 | 150.6 qC | 149.8 qC | 150.9 qC | 165.8 qC |
2 | 120.9 CH | 126.2 CH | 124.9 CH | 80.1 CH |
3 | 53.2 CH | 49.7 CH | 50.8 CH | 120.0 CH |
4 | 87.6 qC | 81.5 qC | 81.3 qC | 144.2 qC |
5 | 32.8 CH2 | 39.7 CH2 | 40.1 CH2 | 36.2 CH2 |
6 | 21.1 CH2 | 24.4 CH2 | 25.4 CH2 | 24.7 CH2 |
7 | 49.6 CH | 56.3 CH | 54.6 CH | 83.9 CH |
8 | 82.8 qC | 74.7 qC | 147.4 qC | 68.8 qC |
9 | 43.5 CH2 | 34.2 CH2 | 24.1 CH2 | 40.8 CH2 |
10 | 24.0 CH2 | 23.4 CH2 | 27.5 CH2 | 23.4 CH2 |
11 | 133.0 CH | 129.9 CH | 59.5 CH | 80.5 CH |
12 | 128.0 qC | 131.0 qC | 58.1 qC | 71.8 qC |
13 | 43.5 CH2 | 43.0 CH2 | 45.6 CH2 | 37.3 CH2 |
14 | 72.9 CH | 70.8 CH | 67.8 CH | 20.6 CH2 |
15 | 26.9 CH | 26.4 CH | 26.7 CH | 121.7 qC |
16 | 25.3 CH3 | 24.7 CH3 | 24.4 CH3 | 9.0 CH3 |
17 | 25.7 CH3 | 26.4 CH3 | 26.4 CH3 | 174.9 qC |
18 | 19.1 CH3 | 23.0 CH3 | 24.1 CH3 | 16.7 CH3 |
19 | 25.1 CH3 | 31.7 CH3 | 111.2 CH2 | 20.5 CH3 |
20 | 20.0 CH2 | 18.8 CH3 | 17.1 CH3 | 23.9 CH3 |
2.2. Cytotoxic Results
3. Experimental Section
3.1. General
3.2. Animal Material
3.3. Extraction and Isolation
3.4. Cytotoxic Bioassays
3.5. Mosher Reaction
3.6. Chemical Conversion
4. Conclusions
Acknowledgments
Conflicts of Interest
References
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Xi, Z.; Bie, W.; Chen, W.; Liu, D.; Ofwegen, L.V.; Proksch, P.; Lin, W. Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans. Mar. Drugs 2013, 11, 3186-3196. https://doi.org/10.3390/md11093186
Xi Z, Bie W, Chen W, Liu D, Ofwegen LV, Proksch P, Lin W. Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans. Marine Drugs. 2013; 11(9):3186-3196. https://doi.org/10.3390/md11093186
Chicago/Turabian StyleXi, Zhifang, Wei Bie, Wei Chen, Dong Liu, Leen Van Ofwegen, Peter Proksch, and Wenhan Lin. 2013. "Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans" Marine Drugs 11, no. 9: 3186-3196. https://doi.org/10.3390/md11093186