Peptide Amphiphiles in Corneal Tissue Engineering
Abstract
:1. Introduction
2. Challenges in Corneal Tissue Engineering
3. Previous Approaches to Engineer Corneal Tissue: Top-Down or Bottom-Up?
4. Peptide Amphiphiles in Tissue Engineering
5. Peptide Amphiphiles as Versatile Templates to Recreate Human Corneas in vitro
PA | Chemical Structure | Aim | Source | [PA] wt % | PA Form | Reference |
---|---|---|---|---|---|---|
C16-C4-G3-S-RGD | | Bone regeneration | Fibronectin | 0.1 | coating | [83] |
C12-HSNGLPLGGGS EEEAAAVVV(K) | | Cartilage regeneration | De novo synthetized | 1 | hydrogel | [84] |
C16-V2A2E2-NH2 | | Cavernous nerve regeneration | De novo synthetized | 0.85 | hydrogel | [87] |
C16-C4-G3- LRKKLGKA | | Blood vessels regeneration | Heparin binding consensus sequence | 3 | hydrogel | [85] |
C16-KTTKS | | Skin regeneration | Procollagen I | 0.0003 | solution | [88] |
PA | Source | Biological Effect | [PA] wt % | PA Form | Reference |
---|---|---|---|---|---|
C16-G3-RGD/RGDS + C16-ETTES | Fibronectin | Enhanced adhesion and proliferation of hCSFs | 1 to 0.005 | coating | [42,96] |
A6-RGDS | Fibronectin | Enhanced adhesion and proliferation of hCSFs | 1 to 0.1 | coating | [97] |
C16-TPGPQGIAGQ-RGDS | MMP cleavage sequence + Fibronectin | Promoted adhesion andgrowth of hCSFs. Stimulated collagen production. Governed tissues lift-up | 2 | coating | [44,74] |
Fmoc-RGDS | Fibronectin | Enhanced cell attachment, proliferation and viability | 1 | solution | [43] |
C16-KTTKS | Procollagen I | Stimulated collagen production from hCSFs | 0.002, 0.004, 0.008 | solution | [98,99] |
C12-VVAGKYIGSR | Laminin | Enhanced keratocyte proliferation and migration, and stimulated collagen I synthesis | 0.2 | coating | [100] |
C16-YEALRVANEVTLN | Lumican | Stimulated collagen I production | 0.01, 0.005, 0.0025 0.00125, 0.000625 | solution | [101] |
6. Future Perspectives
7. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Miotto, M.; Gouveia, R.M.; Connon, C.J. Peptide Amphiphiles in Corneal Tissue Engineering. J. Funct. Biomater. 2015, 6, 687-707. https://doi.org/10.3390/jfb6030687
Miotto M, Gouveia RM, Connon CJ. Peptide Amphiphiles in Corneal Tissue Engineering. Journal of Functional Biomaterials. 2015; 6(3):687-707. https://doi.org/10.3390/jfb6030687
Chicago/Turabian StyleMiotto, Martina, Ricardo M. Gouveia, and Che J. Connon. 2015. "Peptide Amphiphiles in Corneal Tissue Engineering" Journal of Functional Biomaterials 6, no. 3: 687-707. https://doi.org/10.3390/jfb6030687