Notochord Cells in Intervertebral Disc Development and Degeneration
Abstract
:1. Introduction
“Know from whence you came. If you know whence you came, there are absolutely no limitations to where you can go.”—James Baldwin
2. Functions and Structure of the Intervertebral Disc
3. Intervertebral Disc Development
3.1. Early Embryo and Node Development
3.2. Notochord Development
3.3. Notochord Signalling
3.4. Role of the Mesenchyme in Intervertebral Disc Development
3.5. Notochord Cell Contribution to the Nucleus Pulposus
4. Intervertebral Disc Degeneration
Notochord Cells and Intervertebral Disc Homeostasis
5. Small Animal Models to Study Intervertebral Disc Development and Degeneration
5.1. Notochord Cells in Animal Models
5.2. Notochord Associated Cre Mouse Strains
6. IVD Disease and Repair: A Mirror of Development?
7. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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McCann, M.R.; Séguin, C.A. Notochord Cells in Intervertebral Disc Development and Degeneration. J. Dev. Biol. 2016, 4, 3. https://doi.org/10.3390/jdb4010003
McCann MR, Séguin CA. Notochord Cells in Intervertebral Disc Development and Degeneration. Journal of Developmental Biology. 2016; 4(1):3. https://doi.org/10.3390/jdb4010003
Chicago/Turabian StyleMcCann, Matthew R., and Cheryle A. Séguin. 2016. "Notochord Cells in Intervertebral Disc Development and Degeneration" Journal of Developmental Biology 4, no. 1: 3. https://doi.org/10.3390/jdb4010003