Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Cohort
2.2. Phenotypic Data: Serum Electrolytes, Sugars/Lipids, Blood and Inflammatory, and Clinical/Disease Traits
2.3. ECG Data
2.4. Statistical Analysis
3. Results
3.1. Association Analysis
3.1.1. Demographics
3.1.2. Serum Electrolytes
3.1.3. Sugars/Lipids
3.1.4. Blood and Inflammatory
3.1.5. Clinical/Disease Traits
3.2. Risk Score Performance to Predict CAD
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Mean ± SD/N (%) | |
---|---|
Sex (male) | 6340 (44.46) |
Age | 40.12 ± 13.11 |
BMI | 29.6 ± 6.16 |
AF | 67 (0.005) |
AR | 156 (0.011) |
CR | 48 (0.003) |
CAD | 527 (0.038) |
T2D | 3308 (0.236) |
Hyperthyroidism | 1369 (0.098) |
Smoking | 3615 (0.258) |
Stroke | 92 (0.007) |
RR | 905.29 ± 131.23 |
PR | 162 ± 22.55 |
QRS | 93.28 ± 10.63 |
QTc | 402.29 ± 18.56 |
PW | 116.15 ± 11.13 |
JT | 309.01 ± 19.78 |
Sex | Age | BMI | Ancestry | ||||
---|---|---|---|---|---|---|---|
b | p | b | p | b | p | p | |
RR | −0.44 | 6.04 × 10−150 | −0.06 | 3.81 × 10−13 | −0.15 | 6.27 × 10−66 | 0.42 |
PR | −0.24 | 3.12 × 10−43 | 0.23 | 8.67 × 10−163 | 0.18 | 1.86 × 10−96 | 7.99 × 10−19 |
QRS | −0.71 | 0 | 0.12 | 1.20 × 10−42 | 0.10 | 1.07 × 10−31 | 3.52 × 10−14 |
QTc | 0.56 | 1.29 × 10−247 | 0.26 | 3.43 × 10−218 | 0.20 | 7.58 × 10−122 | 2.12 × 10−4 |
PW | −0.29 | 2.05 × 10−66 | 0.23 | 2.01 × 10−168 | 0.27 | 9.14 × 10−222 | 2.55 × 10−6 |
JT | 0.91 | 0 | 0.18 | 1.84 × 10−106 | 0.13 | 8.13 × 10−55 | 0.04 |
Risk Score | ||||||
---|---|---|---|---|---|---|
OR | OR 95% CI | p | OR Decile | AUC | AUC 95% CI | |
Multivariate regression | ||||||
BMI + Ancestry | 1.24 | [1.06, 1.46] | 6.34 × 10−3 | 1.36 | 0.56 | [0.52, 0.61] |
Sex + Age | 3.84 | [3.21, 4.59] | 3.55 × 10−49 | 11.73 | 0.84 | [0.81, 0.87] |
PR + QRS + QTc | 1.65 | [1.45, 1.88] | 4.00 × 10−14 | 3.76 | 0.66 | [0.61, 0.7] |
HDL + HbA1C | 2.04 | [1.8, 2.32] | 9.88 × 10−29 | 7.57 | 0.75 | [0.7, 0.79] |
Chloride + Magnesium + Potassium + Calcium | 1.76 | [1.52, 2.04] | 1.94 × 10−14 | 4.32 | 0.64 | [0.59, 0.69] |
SBP + DBP + Smoking + T2D + Stroke | 2.85 | [2.46, 3.31] | 8.76 × 10−44 | 9.29 | 0.8 | [0.77, 0.84] |
SBP + DBP + Smoking + T2D + Stroke + RR + PR + QRS + QTc + HbA1C + Magnesium + Potassium + Ancestry | 2.85 | [2.46, 3.3] | 2.20 × 10−44 | 9.57 | 0.81 | [0.77, 0.85] |
xgboost | ||||||
T2D + HbA1C + TC + QRS + SBP + QTc + Smoking + Glucose + RR + Potassium + LDL-C + PW + TG + BMI + DBP + Insulin + Stroke + HDL-C + PR | 2.06 | [1.87, 2.28] | 2.10 × 10−46 | 13.99 | 0.84 | [0.81, 0.88] |
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Qafoud, F.; Kunji, K.; Elshrif, M.; Althani, A.; Salam, A.; Al Suwaidi, J.; Darbar, D.; Asaad, N.; Saad, M. Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort. J. Clin. Med. 2024, 13, 276. https://doi.org/10.3390/jcm13010276
Qafoud F, Kunji K, Elshrif M, Althani A, Salam A, Al Suwaidi J, Darbar D, Asaad N, Saad M. Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort. Journal of Clinical Medicine. 2024; 13(1):276. https://doi.org/10.3390/jcm13010276
Chicago/Turabian StyleQafoud, Fatima, Khalid Kunji, Mohamed Elshrif, Asma Althani, Amar Salam, Jassim Al Suwaidi, Dawood Darbar, Nidal Asaad, and Mohamad Saad. 2024. "Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort" Journal of Clinical Medicine 13, no. 1: 276. https://doi.org/10.3390/jcm13010276