Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion
Abstract
:1. Introduction
2. Interleukin 27 Conformation and Its Biological Function in Immunity
3. Interleukin 27 in Infectious Pathology
4. Interleukin 27 in COVID-19
5. Conclusions
6. Future Directions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Year of Publication | Authors | Findings | Reference |
---|---|---|---|
2021 | Arsentieva N.A. et al. | Increase in IL-27 levels in acute COVID-19 patients vs. healthy donors (p < 0.0001); decrease in IL-27 concentrations in convalescents when compared to healthy donors (p = 0.0015). | [56] |
2022 | Arsentieva N.A. et al. | IL-27 showed a statistically significant increase in concentrations in COVID-19 acute patients when compared to healthy donors (p < 0.001 for non-survivors and p < 0.05 for survivors). | [61] |
2022 | Korobova Z.R. et al. | IL-27 was one of the four biological markers showing statistically significant changes in concentrations in the blood plasma of patients infected with different variants of SARS-CoV-2 (p < 0.001). | [64] |
2022 | Kudryavtsev I.V. et al. | The correlation between Tc17 cells of central memory and TEMRA cells and serum IL-27 levels was negative in patients with acute COVID-19, a tendency not observed in convalescent or healthy donors. | [65] |
2022 | Zamani B. et al. | IL-27, along with IL-32 and neutrophil-to-lymphocyte ratio (NLR), was highlighted as one of the markers of severe COVID-19 and lethal outcomes. | [57] |
2022 | Klingler J. et al. | In patients with higher demographic risk factors (i.e., male, black/Hispanic descent, and median age over 63 years old), IL-27 was suggested as one of the factors to prove the need for hospitalization. | [58] |
2023 | Laatifi M. et al. | The COVID-19 prognosis was based on machine learning and included several cytokines, including IL-27, along with IL-9, IL-12p40, and MCP-3, to play the role of markers for non-severe COVID-19. | [60] |
2023 | Valdés-López and Urcuqui-Inchima | IL-27 triggers a strong pro-inflammatory and antiviral reaction that relies on STAT1 without requiring IFN in COVID-19-derived PBMCs and monocytes, which is linked to a severe clinical outcome of COVID-19. This effect is also seen in macrophages that have been stimulated by S protein. | [62] |
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Korobova, Z.R.; Arsentieva, N.A.; Santoni, A.; Totolian, A.A. Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion. Int. J. Mol. Sci. 2024, 25, 7953. https://doi.org/10.3390/ijms25147953
Korobova ZR, Arsentieva NA, Santoni A, Totolian AA. Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion. International Journal of Molecular Sciences. 2024; 25(14):7953. https://doi.org/10.3390/ijms25147953
Chicago/Turabian StyleKorobova, Zoia R., Natalia A. Arsentieva, Angela Santoni, and Areg A. Totolian. 2024. "Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion" International Journal of Molecular Sciences 25, no. 14: 7953. https://doi.org/10.3390/ijms25147953