The CHD Protein Kismet Restricts the Synaptic Localization of Cell Adhesion Molecules at the Drosophila Neuromuscular Junction
Abstract
:1. Introduction
2. Results
2.1. kis Restricts the Synaptic Localization of CAMs
2.2. Impairing Vesicle Trafficking Increases Synaptic FasII in Wild-Type Larvae but Does Not Change Synaptic FasII in kis Mutants
2.3. Increased Rab11 Activity Promotes the Synaptic Localization of FasII in Wild-Type Larvae and Shows an Additive Effect in kis Mutants
3. Discussion
4. Materials and Methods
4.1. Drosophila Stocks and Husbandry
4.2. Chromatin Immunoprecipitation, RNA Isolation, Reverse Transcription PCR, and qPCR
4.3. Immunocytochemistry
4.4. Larval Locomotion
4.5. Experimental Design and Statistical Analyses
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Smith, I.R.; Hendricks, E.L.; Latcheva, N.K.; Marenda, D.R.; Liebl, F.L.W. The CHD Protein Kismet Restricts the Synaptic Localization of Cell Adhesion Molecules at the Drosophila Neuromuscular Junction. Int. J. Mol. Sci. 2024, 25, 3074. https://doi.org/10.3390/ijms25053074
Smith IR, Hendricks EL, Latcheva NK, Marenda DR, Liebl FLW. The CHD Protein Kismet Restricts the Synaptic Localization of Cell Adhesion Molecules at the Drosophila Neuromuscular Junction. International Journal of Molecular Sciences. 2024; 25(5):3074. https://doi.org/10.3390/ijms25053074
Chicago/Turabian StyleSmith, Ireland R., Emily L. Hendricks, Nina K. Latcheva, Daniel R. Marenda, and Faith L. W. Liebl. 2024. "The CHD Protein Kismet Restricts the Synaptic Localization of Cell Adhesion Molecules at the Drosophila Neuromuscular Junction" International Journal of Molecular Sciences 25, no. 5: 3074. https://doi.org/10.3390/ijms25053074