The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut
Abstract
:1. Introduction
2. H4R Basics
3. Histamine in the Intestine
4. Histamine Receptors in the Intestine
5. Histamine-Responsive Cells
6. Histamine and Carcinogenesis
7. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Cell Type | Mouse | Human | Reference |
---|---|---|---|
CD4+ T cell | x | [26] | |
Th2 | x | [27] | |
Th9 | x | [28] | |
Th17 | x | x | [29,30,31] |
Treg | x | x | [32,33] |
γδ T cell | x | [34] | |
CD8+ T cell | x | [35] | |
DC | x | x | [36,37,38,39,40,41,42,43,44,45,46,47] |
NKT | x | [48] | |
Mast cell | x | x | [26,49,50,51,52,53,54,55,56,57,58,59] |
Neutrophil | x | x | [23,26,60,61] |
Monocyte | x | [26,36,60,62,63] | |
MΦ | x | [64] | |
M1 | x | [65,66] | |
M2 | x | [67] | |
Basophil | x | [49,68,69] | |
Eosinophil | x | x | [26,38,49,60,70,71,72,73,74,75,76,77] |
NK cell | x | [43,78,79] |
Main Findings | Species | Ref. |
---|---|---|
H2R and H4R are pro-proliferative and pro-angiogenic in HT29, Caco-2, and HCT116 colon cancer cell lines | human | [125] |
H4R possesses pro-inflammatory role in TNBS-induced colitis in rats | rat | [124] |
H1R, H2R, H4R are expressed in the human gastrointestinal tract; expression is altered in patients with gastrointestinal diseases | human | [24] |
H1R, H2R, H3R, H4R activation excite human enteric neurons | human | [25] |
H1R, H2R, and H4R are expressed in colon carcinoma and in adjacent normal mucosa; H1R and H4R expression is reduced in carcinoma compared to normal colon | human | [126] |
H1R, H2R, and H4R are expressed in simian colon smooth muscle cells | mouse, monkey | [121] |
H4R activity contributes to radiation-induced cytotoxic and genotoxic damages in small intestine | rat | [127] |
H4R stimulates the release of DAO, contributing to histamine deamination during fat absorption | rat | [128] |
H4R and H1R contribute to post-inflammatory visceral hypersensitivity | rat | [129] |
H4R possesses a pro-inflammatory role in DSS-induced colitis in mice | mouse | [89] |
H1R and H4R regulate the DC-CD4+ T-cell axis in peanut-induced intestinal allergic responses | mouse | [130] |
H4R possesses an anti-inflammatory role in TNBS-induced colitis in mice | mouse | [90] |
H4R possesses a pro-inflammatory role in experimental colitis in mice | mouse | [23] |
H4R is functionally expressed on colon epithelial cells, affecting epithelial barrier integrity | mouse | [22] |
H4R is involved in carcinogenesis of chemically-induced colitis-associated colorectal carcinoma | mouse | [131] |
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Schirmer, B.; Neumann, D. The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut. Int. J. Mol. Sci. 2021, 22, 6116. https://doi.org/10.3390/ijms22116116
Schirmer B, Neumann D. The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut. International Journal of Molecular Sciences. 2021; 22(11):6116. https://doi.org/10.3390/ijms22116116
Chicago/Turabian StyleSchirmer, Bastian, and Detlef Neumann. 2021. "The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut" International Journal of Molecular Sciences 22, no. 11: 6116. https://doi.org/10.3390/ijms22116116