Acyl-CoA-Binding Domain-Containing 3 (ACBD3; PAP7; GCP60): A Multi-Functional Membrane Domain Organizer
Abstract
:1. Introduction
2. ACBD3 in Steroidogenesis
3. ACBD3 in Lipid Metabolism and Metabolic Homoeostasis
4. ACBD3 in Regulation of Ceramide and Glucosylceramide Transport
5. ACBD3 in Golgi Structure Maintenance
6. ACBD3 in Iron Uptake
7. ACBD3 Is Exploited by Viral and Bacterial Proteins to Promote Their Replication
8. ACBD3 in Intracellular Retention of GLUT4 Storage Vesicles (GSV)
9. ACBD3 in Huntington’s Disease (HD)
10. ACBD3 in Cancer
11. Conclusions
Funding
Conflicts of Interest
References
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Protein Names | Molecular Weight | Intracellular Localization | Functions | References |
---|---|---|---|---|
Giantin | 372 kDa | Golgi | Golgi organization; ER to Golgi transport | [6] |
Golgin160 | 160 kDa | Golgi | Maintenance of Golgi structure | [7,8] |
Golgin45 | 45 kDa | Golgi and nucleus | Required for normal Golgi structure and for protein transport from the ER through the Golgi to the cell surface | [11] |
Numb | 72 kDa | plasma membrane, nucleus and cytosol | Plays a role in the determination of cell fates during development | [19] |
PI4KB | 92 kDa | Golgi, endosome and cytosol | May regulate Golgi disintegration/reorganization during mitosis; Involved in Golgi-to-plasma membrane trafficking | [10,17,21,42,44,45] |
TUG | 60 kDa | plasma membrane, nucleus and cytosol | Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Enhances VCP methylation catalyzed by VCPKMT. | [12] |
Htt | 35 kDa | cytoskeleton, nucleus, cytosol, ER, Golgi and endosome | Huntingtin is a disease gene linked to Huntington’s disease; May play a role in microtubule-mediated transport or vesicle function | [13] |
PBR | 18 kDa | mitochondria | Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism | [26] |
PRKAR1A | 43 kDa | plasma membrane and cytosol | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | [26] |
3A protein | Nonstructural viral protein required for RNA replication | [14,23,24,42,44,45] | ||
SseF and SseG | Both are (Salmonella pathogenicity island 2) SPI-2-encoded effectors which are necessary for the retention of tightly clustered bacterial microcolonies in close proximity to the MTOC and the Golgi | [22] | ||
DMT1 | 62 kDa | plasma membrane, mitochondria, nucleus lysosome, endosome and Golgi | Important in metal transport, in particular iron | [16] |
PARP1 | 110 kDa | Mitochondria and nucleus | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism | [20] |
SREBP1 | 120 kDa | ER, nucleus, cytosol and Golgi | Transcriptional activator required for lipid homeostasis | [28] |
FAPP2 | 58 kDa | nucleus and Golgi | Cargo transport protein that is required for apical transport from the Golgi complex; Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids | [9] |
TBC1D22A | 47 kDa | Perinuclear, Golgi | GTPase activating protein (GAP) for Rab33b; membrane trafficking | [14] |
PPM1L | 41 kDa | ER | Helps regulate ceramide transport from the ER to the Golgi; Acts as a suppressor of the SAPK signaling pathways | [15] |
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Yue, X.; Qian, Y.; Gim, B.; Lee, I. Acyl-CoA-Binding Domain-Containing 3 (ACBD3; PAP7; GCP60): A Multi-Functional Membrane Domain Organizer. Int. J. Mol. Sci. 2019, 20, 2028. https://doi.org/10.3390/ijms20082028
Yue X, Qian Y, Gim B, Lee I. Acyl-CoA-Binding Domain-Containing 3 (ACBD3; PAP7; GCP60): A Multi-Functional Membrane Domain Organizer. International Journal of Molecular Sciences. 2019; 20(8):2028. https://doi.org/10.3390/ijms20082028
Chicago/Turabian StyleYue, Xihua, Yi Qian, Bopil Gim, and Intaek Lee. 2019. "Acyl-CoA-Binding Domain-Containing 3 (ACBD3; PAP7; GCP60): A Multi-Functional Membrane Domain Organizer" International Journal of Molecular Sciences 20, no. 8: 2028. https://doi.org/10.3390/ijms20082028