New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise
Abstract
:1. Introduction
2. Anti-Body Drug Conjugate (ABDC)
Gemtuzumab Ozogamicin (GO)
3. FLT3-Inhibitors
3.1. Sorafenib
3.2. Midostaurin
3.3. Quizartinib
3.4. Crenolanib
3.5. Gilteritinib
4. IDH inhibitors
4.1. Enasidenib
4.2. Ivosidenib
5. Hedgehog Inhibition
Glasdegib
6. BCL2 Inhibition
Venetoclax
7. Upcoming Agents
8. Future Perspectives
9. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Agents | Investigation | Phase | Identifier |
---|---|---|---|
Gemtuzumab Ozogamicin | Liposome-encapsulated daunorubicin-cytarabine and GO in treating patients with r/r AML or high-risk MDS | 1 | NCT03672539 |
Fractionated GO in treating MRD measurable residual disease in participants with AML | 2 | NCT03737955 | |
Sorafenib | Sorafenib + busulfan and fludarabine conditioning in r/r AML undergoing stem cell transplantation | 1/2 | NCT03247088 |
Sorafenib plus azacitidine in AML/MDS patients with FLT3-ITD mutation | 2 | NCT02196857 | |
Midostaurin | Midostaurin + chemotherapy in newly diagnosed FLT3-WT AML | 3 | NCT03512197 |
Crenolanib vs. midostaurin following induction chemotherapy and consolidation therapy in newly diagnosed FLT3 mutant AML | 3 | NCT03258931 | |
Quizartinib | Quizartinib with standard of care chemotherapy and as continuation therapy in new diagnosed FLT3-ITD AML | 3 | NCT02668653 |
Quizartinib and venetoclax in r/r FLT3 mutated AML | 1b/2 | NCT03735875 | |
Crenolanib | Crenolanib combined with chemotherapy in r/r FLT3 mutated AML | 1b/2 | NCT02298166 |
Crenolanib maintenance following allogeneic stem cell transplantation in FLT3-mutant AML | 2 | NCT02400255 | |
Gilteritinib | Gilteritinib vs. midostaurin in FLT3 mutant AML during induction and consolidation chemotherapy | 2 | NCT03836209 |
Gilteritinib as maintenance therapy following induction/consolidation therapy in FLT3-ITD AML in 1.CR | 3 | NCT02927262 | |
Enasidenib/Ivosidenib | Ivosidenib or Enasidenib combined with induction/consolidation, followed by maintenance therapy in IDH1/IDH2 mutated AML/MDS2-EB2 | 3 | NCT03839771 |
Enasidenib vs. conventional care regimens in IDH2 mutant elderly AML | 3 | NCT02577406 | |
Ivosidenib vs. placebo in combination with azacitidine in IDH1 mutant AML | 3 | NCT03173248 | |
Glasdegib | Intensive chemotherapy +/− glasdegib or azacitidine +/− glasdegib AML patients | 3 | NCT03416179 |
Immunotherapy combinations for AML for example, glasdegib plus avelumab | 1b/2 | NCT03390296 | |
Venetoclax | Venetoclax combined with gilteritinib in r/r AML | I | NCT03625505 |
Venetoclax +/− azacitidine in AML, ineligible for intensive treatment | 3 | NCT02993523 | |
Venetoclax +/− low dose cytarabine in AML, ineligible for intensive treatment | 3 | NCT03069352 | |
Venetoclax combined with induction/consolidation chemotherapy in AML | 1b | NCT03709758 |
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Bohl, S.R.; Bullinger, L.; Rücker, F.G. New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise. Int. J. Mol. Sci. 2019, 20, 1983. https://doi.org/10.3390/ijms20081983
Bohl SR, Bullinger L, Rücker FG. New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise. International Journal of Molecular Sciences. 2019; 20(8):1983. https://doi.org/10.3390/ijms20081983
Chicago/Turabian StyleBohl, Stephan R., Lars Bullinger, and Frank G. Rücker. 2019. "New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise" International Journal of Molecular Sciences 20, no. 8: 1983. https://doi.org/10.3390/ijms20081983