Oncolytic Activities of Host Defense Peptides
Abstract
:1. Introduction
1.1. Host Defense Peptides
1.2. Structure and Mechanism of Action
2. α-Helical Oncolytic Peptides
2.1. BMAP-27 & BMAP-28
2.2. Cecropin A and B
2.3. LL-37/hCAP-18
2.4. Magainins
2.5. Mellitin
3. B-Sheet Oncolytic Peptides
3.1. Defensins
3.2. Lactoferricin
3.3. Tachyplesin
4. Hybrid and Synthetic HDPs
4.1. Buforin II and Buforin IIb
4.2. Hunter-Killer Peptides
4.3. Polybia-MPI
4.4. Epinecidin-1
4.5. d,l-Amino Acids Host-Defence-like Peptides
5. Discussion
6. Conclusion
Acknowledgements
References
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Peptide | Cancer cell | Study | Reference |
---|---|---|---|
Polybia-MPI | Human bladder and prostate | In vitro, compared against murine fibroblasts | Wang et al. 2008 |
Tachyplesin | Prostate cancer cell line | In vitro and syngenic mouse model | Chen et al. 2001 |
Buforin IIb | 62 different cancer cell lines | In vivo mouse xenograft model | |
Human breast cancer cell line | In vitro | Furlong et al. 2006 | |
Human neuroblastoma cell lines | In vitro and neuroblastoma mouse xenograft model | Eliassen et al. 2006 | |
Bovine lactoferricin | Jurkat T-leukemia cells | In vitro | Mader et al. 2007 |
adenocarcinoma | In vivo tumor induced F344 rats | Tsuda et al. 1998 | |
Human monocytic leukemic cells | In vitro | Yoo et al. 1997 | |
Cecropin A and B | Bladder cancer cells | In vitro | Suttmann et al. 2008 |
Human alpha-defensin-1 | Human lung adenocarcinoma | Mouse xenograft model | Xu et al. 2008 |
Human alpha-defensin-1 and lactoferrin | oral squamous cell carcinoma | In vitro | McKeown et al. 2006 |
Human beta-defensin-1 | Prostate cancer cell lines | In vitro | Bullard et al. 2008 |
hCAP-18(109–135) | oral squamous cell carcinoma | In vitro | Okumura et al. 2004 |
Magainin II | Bladder cancer cell line hematopoietic tumor and solid tumor target cells | In vitro | Lehmann et al. 2006 |
In vitro | Cruciani et al. 1991 | ||
Magainin II and derivatives | Several cell lines | In vivo ovarian cancer model | Baker et al. 1993 |
MSI-511 (Magainin derivative) | Several human melanoma cell lines | In vitro | Soballe et al. 1995 |
Magainin A and G | Small cell lung cancer cell lines | In vitro | Ohsaki et al. 1992 |
Sythetic 9-mer d-peptides | Mouse myeloma cell line | In vitro | Iwasaki et al. 2009 |
CA-ME (hybrid peptide) | Small cell lung cancer cell lines | In vitro | Shin et al. 1997 |
Prostate carcinoma cell lines | Mouse xenograft model | Papo et al. 2004 | |
Synthetic l/d-peptides | Primary human prostate and breast cancer cells | Prevents metastases in mouse xenograft model | Papo et al. 2006 |
Mouse melanoma and lung cancer cell lines | Mouse xenograft model | Papo et al. 2003 | |
Human liposarcoma and synovial sarcoma cells | Mouse xenograft model | Steinstraeser et al. 2011 |
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Al-Benna, S.; Shai, Y.; Jacobsen, F.; Steinstraesser, L. Oncolytic Activities of Host Defense Peptides. Int. J. Mol. Sci. 2011, 12, 8027-8051. https://doi.org/10.3390/ijms12118027
Al-Benna S, Shai Y, Jacobsen F, Steinstraesser L. Oncolytic Activities of Host Defense Peptides. International Journal of Molecular Sciences. 2011; 12(11):8027-8051. https://doi.org/10.3390/ijms12118027
Chicago/Turabian StyleAl-Benna, Sammy, Yechiel Shai, Frank Jacobsen, and Lars Steinstraesser. 2011. "Oncolytic Activities of Host Defense Peptides" International Journal of Molecular Sciences 12, no. 11: 8027-8051. https://doi.org/10.3390/ijms12118027