Porphyrin Photosensitizers into Polysaccharide-Based Biopolymer Hydrogels for Topical Photodynamic Therapy: Physicochemical and Pharmacotechnical Assessments
Abstract
:1. Introduction
2. Results and Discussion
2.1. Physicochemical Characterization of the Gels
2.1.1. FTIR Spectroscopy
2.1.2. XRD Analysis
2.1.3. Thermal Analysis
2.1.4. AFM Results
2.1.5. UV-Vis and Fluorescence Spectroscopy
2.2. Pharmacotechnical Evaluation of the Porphyrin Gels
2.2.1. Wet Gels Evaluation
pH Values
Spreadability
In Vitro Adhesion Ability
Rheology Measurements
Dry Gels Evaluation
2.3. Discussion
3. Conclusions
4. Materials and Methods
4.1. Materials
4.2. The Formulation and Manufacturing Process of the Hydrogels
4.3. Physicochemical Characterization of the Gels
4.4. Pharmacotechnical Evaluation of the Porphyrin Gels
4.4.1. Wet Gels Evaluation
pH Determination
Spreadability
In Vitro Adhesion Ability
Rheology Measurements
Dry Gels Evaluation
Mechanical Properties
- Thickness
Tensile Strength and Elongation
Moisture Content
Swelling Ratio
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Compound | 1st Step (Temperature and Mass Loss) | 2nd Step (Temperature and Mass Loss) | Remaining Mass at 600 °C |
---|---|---|---|
HPC | Below 100 °C/2.4% | TDTA = 365 °C and TDTG = 355 °C TDTA = 495 °C and TDTG = 501 °C | No residue |
HPC P2.1. | Below 100 °C/1.8% | TDTA = 367 °C and TDTG = 357 °C TDTA = 491 °C and TDTG = 487 °C | No residue |
HPC P2.2. | Below 100 °C/2.2% | TDTA = 367 °C and TDTG = 361 °C TDTA = 492 °C and TDTG = 489 °C | No residue |
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Burloiu, A.M.; Ozon, E.A.; Musuc, A.M.; Anastasescu, M.; Socoteanu, R.P.; Atkinson, I.; Culita, D.C.; Anuta, V.; Popescu, I.A.; Lupuliasa, D.; et al. Porphyrin Photosensitizers into Polysaccharide-Based Biopolymer Hydrogels for Topical Photodynamic Therapy: Physicochemical and Pharmacotechnical Assessments. Gels 2024, 10, 499. https://doi.org/10.3390/gels10080499
Burloiu AM, Ozon EA, Musuc AM, Anastasescu M, Socoteanu RP, Atkinson I, Culita DC, Anuta V, Popescu IA, Lupuliasa D, et al. Porphyrin Photosensitizers into Polysaccharide-Based Biopolymer Hydrogels for Topical Photodynamic Therapy: Physicochemical and Pharmacotechnical Assessments. Gels. 2024; 10(8):499. https://doi.org/10.3390/gels10080499
Chicago/Turabian StyleBurloiu, Andreea Mihaela, Emma Adriana Ozon, Adina Magdalena Musuc, Mihai Anastasescu, Radu Petre Socoteanu, Irina Atkinson, Daniela C. Culita, Valentina Anuta, Ioana Andreea Popescu, Dumitru Lupuliasa, and et al. 2024. "Porphyrin Photosensitizers into Polysaccharide-Based Biopolymer Hydrogels for Topical Photodynamic Therapy: Physicochemical and Pharmacotechnical Assessments" Gels 10, no. 8: 499. https://doi.org/10.3390/gels10080499