Extracellular Vesicles in Aging: An Emerging Hallmark?
Abstract
:1. Introduction
2. Aging
2.1. Mitochondrial Dysfunction Associated with ROS Generation
2.2. Deregulated Nutrient Sensing
2.3. Cell Senescence
3. EVs in Aging and Senescence
3.1. Cellular Senescence and EVs
3.2. Body Fluid EVs and Aging
Organism | EVs Source | miRNA | Reference | |
---|---|---|---|---|
Up Regulated | Downregulated | |||
Mice | Serum | miR-34a | Fulzele et al., 2019 [136] | |
Serum | miR-192 | Tsukamoto et al., 2020 [145] | ||
Plasma | miR-146a miR-21 miR-22 miR-223 miR-145 let-7a | miR-212 miR-455 | Alibhai et al., 2020 [127] | |
Bone marrow interstitial fluid | miR-96 miR-182 miR-183 | Davis et al., 2017 [139] | ||
Human | Plasma | miR-31 | Weilner et al., 2016 [137] | |
Plasma | miR-21-5p | Mensà et al., 2020 [102] | ||
Follicular fluid | miR-125b miR-155-5p miR-372 | miR-16-5p miR-214-3p miR-449a | Battaglia et al., 2020 [128] | |
Saliva | miR-24-3p | Matchida et al., 2015 [138] |
4. Anti-Aging Potential of EVs from Various Sources
4.1. In Vitro Studies
4.2. In Vivo Studies
5. Microbiota-Derived EVs and Aging
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Manni, G.; Buratta, S.; Pallotta, M.T.; Chiasserini, D.; Di Michele, A.; Emiliani, C.; Giovagnoli, S.; Pascucci, L.; Romani, R.; Bellezza, I.; et al. Extracellular Vesicles in Aging: An Emerging Hallmark? Cells 2023, 12, 527. https://doi.org/10.3390/cells12040527
Manni G, Buratta S, Pallotta MT, Chiasserini D, Di Michele A, Emiliani C, Giovagnoli S, Pascucci L, Romani R, Bellezza I, et al. Extracellular Vesicles in Aging: An Emerging Hallmark? Cells. 2023; 12(4):527. https://doi.org/10.3390/cells12040527
Chicago/Turabian StyleManni, Giorgia, Sandra Buratta, Maria Teresa Pallotta, Davide Chiasserini, Alessandro Di Michele, Carla Emiliani, Stefano Giovagnoli, Luisa Pascucci, Rita Romani, Ilaria Bellezza, and et al. 2023. "Extracellular Vesicles in Aging: An Emerging Hallmark?" Cells 12, no. 4: 527. https://doi.org/10.3390/cells12040527