The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders
Abstract
:1. Introduction
2. Ferroptosis and Central Neurological Disorders
2.1. Mechanism and Pathway of Ferroptosis
2.2. Ferroptosis in Central Neurological Disorders
2.3. Cognitive Dysfunction Caused by Ferroptosis
3. Neuroinflammation in Central Neurological Disorders
4. The Link between Neuroinflammation and Ferroptosis
4.1. Molecular Mechanisms and Signaling Pathways
4.1.1. SIRT1
4.1.2. Nrf2
4.1.3. NF-κB
4.1.4. PTGS2/Cox-2
4.1.5. iNOS/NO•
4.2. Cell Phenotype and Specific Structure
4.2.1. Blood–Brain Barrier
4.2.2. Microglia
4.2.3. Astrocytes
4.2.4. Neutrophils and NETs
4.2.5. T Cells
5. Conclusions
6. Futures Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Xu, Y.; Jia, B.; Li, J.; Li, Q.; Luo, C. The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders. Antioxidants 2024, 13, 395. https://doi.org/10.3390/antiox13040395
Xu Y, Jia B, Li J, Li Q, Luo C. The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders. Antioxidants. 2024; 13(4):395. https://doi.org/10.3390/antiox13040395
Chicago/Turabian StyleXu, Yejia, Bowen Jia, Jing Li, Qianqian Li, and Chengliang Luo. 2024. "The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders" Antioxidants 13, no. 4: 395. https://doi.org/10.3390/antiox13040395