A Dietary Supplement Containing Plant Sterols Exerts a Positive Effect on Inflammatory Markers in a Chronic Colitis Murine Model †
Abstract
:1. Introduction
2. Materials and Methods
2.1. Preparation of the Dietary Supplements of Plant Sterols
2.2. Animals and Chronic Ulcerative Colitis Model
2.3. Myeloperoxidase Activity
2.4. Cytokine Determination
2.5. Statistical Analysis
3. Results and Discussion
3.1. Plant Sterols Inhibit Neutrophil Infiltration in Mice Colon
3.2. Effect of Plant Sterols on Cytokine Expression in Mice Colon
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Groups | TNF-α | IL-6 | IL-10 |
---|---|---|---|
Control + placebo | 8.1 ± 1.1 a | 18.6 ± 1.7 a | 281.1 ± 45.7 a |
Control + PS-DS | 6.5 ± 0.6 a | 21.2 ± 1.8 a | 246.8 ± 19.5 a |
DSS + placebo (treatment) | 85.1 ± 11.1 b | 213.7 ± 25.6 b | 46.2 ± 5.0 b |
DSS + PS-DS (treatment) | 38.5 ± 6.8 c | 127.9 ± 17.6 c | 135.8 ± 15.7 c |
DSS + placebo (pre-treatment) | 55.7 ± 7.8 c | 145.5 ± 19.6 c | 50.3 ± 8.9 b |
DSS + PS-DS (pre-treatment) | 20.8 ± 0.7 d | 83.2 ± 9.7 d | 178.2 ± 30.1 c |
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Makran, M.; Giner, R.M.; Cilla, A.; Recio, M.C.; Garcia-Llatas, G. A Dietary Supplement Containing Plant Sterols Exerts a Positive Effect on Inflammatory Markers in a Chronic Colitis Murine Model. Biol. Life Sci. Forum 2023, 26, 57. https://doi.org/10.3390/Foods2023-15158
Makran M, Giner RM, Cilla A, Recio MC, Garcia-Llatas G. A Dietary Supplement Containing Plant Sterols Exerts a Positive Effect on Inflammatory Markers in a Chronic Colitis Murine Model. Biology and Life Sciences Forum. 2023; 26(1):57. https://doi.org/10.3390/Foods2023-15158
Chicago/Turabian StyleMakran, Mussa, Rosa María Giner, Antonio Cilla, María Carmen Recio, and Guadalupe Garcia-Llatas. 2023. "A Dietary Supplement Containing Plant Sterols Exerts a Positive Effect on Inflammatory Markers in a Chronic Colitis Murine Model" Biology and Life Sciences Forum 26, no. 1: 57. https://doi.org/10.3390/Foods2023-15158