Serum ferritin status and mitochondrial function in children

Authors

  • Elham KhAljammas Professor in community psychiatry, University of Ninevah, college of medicine, Department of medicine, Mosul, Iraq
  • Muhammed A Ahmed Al Kataan Assistant Professor in Molecular Biochemistry and Stem Cell Biology, College of Medicine, Ninevah University, Mosul-Iraq
  • Nashwan M Al Hafidh Professor of Pediatrics, Ninevah University, college of medicine, pediatric Department, Mosul, Iraq

DOI:

https://doi.org/10.3329/bjms.v22i2.64998

Keywords:

Serum ferritin; mitochondrial function

Abstract

objective: Iron is the most abundant metal within the mitochondrial matrix . Ferritin reflects bodyironstores. This study aimed to assess the association between serum ferritin levels and mitochondrial function in children.

Methods: Two hundred and forty-three children from four governmental primary schools in Mosul city in Iraq were randomly selected by a multistage random sampling method. Their age range was 6-12 years. Mitochondrial function tests involved measurement of serum lactate, serum pyruvate, and L-Carnitine were analyzed in all selected children along with serum ferritin.

Results: Lower levels of serum ferritin weresignificantly associated with higher levels of serum lactate, serum lactate/serum pyruvate ratio. There was a significant negative correlation (p = 0.000, - 0.296,- 0.286) between mean serum ferritin level and mean serum lactate, serum lactate / serum pyruvate ratio respectively.There were significant differences (p= 0.000) in mean serum level of mitochondrial function tests (Lactate, L- Carnation, and L/P ratio) in comparing children possessing a normal level of serum ferritin versus those with a low serum ferritin level of < 12 ng/ml. ROC analysis showed that when the area under the curve (AUC) was 0.761 ± SE 0.37, a cut off value 4.79 ng/ml of serum ferritin was significantly (p=0 .000) associated with sensitivity of 100 % and 1- specificity of 0.861 value with presence of L: P molar ratio of ≤ equal 20.

Conclusion:Serum ferritin < 12 ng/ ml represntsmitochondrial deficient level. Serum ferritin < 4.79 ng/ml was the critical value at which only 8.6% of children will have a healthy mitochondrial function.

Bangladesh Journal of Medical Science Vol. 22 No. 02 April’23 Page : 374-378

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Published

2023-04-11

How to Cite

KhAljammas, E. ., Kataan, M. A. A. A. ., & Hafidh, N. M. A. (2023). Serum ferritin status and mitochondrial function in children. Bangladesh Journal of Medical Science, 22(2), 374–378. https://doi.org/10.3329/bjms.v22i2.64998

Issue

Vol. 22 No. 2 (2023)

Section

Original Articles

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Copyright (c) 2023 Elham KhAljammas, Muhammed A Ahmed Al Kataan, Nashwan M Al Hafidh

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