Prevention and rehabilitation efficiency can greatly benefit from the application of intelligent, 24 hour tele-diagnostics and tele-care information systems. Tele-monitoring also supports a new level of medical supervision over the patient's lifestyle. In this paper we briefly present the architecture and development phase results of the Alpha remote monitoring system. The novelty of the system is the unified and flexible processing of various signals retrieved from modern, unobtrusive devices in an efficient signal abstraction framework. The signals include PIR motion sensors that record patient movement in the home, physiological signals and also patient responses in various tests performed on the GUI of the central home unit. We have developed and tested the prototype system with promising results.