The aim of research was to define the influence treatment methods involving application of growth biostimulators and herbicide on the total yield of edible potato. The field research was conducted in 2015-2017 in the area of eastern Poland, in Lublin Voivodship. The experiments were performed in three replications using the randomized split-block method. Examined factors were: The examined factors included: I. factor – three early cultivars of edible potato (Owacja, Bellarosa, Vineta), II. factor – treatment methods involving application of growth biostimulators and herbicide: GreenOK-Universal Pro and Asahi SL as well as their combination with the Avatar 293 ZC herbicide. The highest total yield of tubers was obtained from object 4., where prior to sprouting, mechanical treatment was used, and after the final shaping of ridges and just before sprouting the Avatar 293 ZC herbicide was applied at a dose of 1.5 dm³ ha^–1, and then after sprouting the GreenOK Universal-PRO was applied three times at doses: 0.10 dm³ ha^–1 – full moon-end of seeding + 0.15 dm³ ha^–1 – covering inter-rows + 0.15 dm³ ha^–1 – formation of flower buds (an average of 41.8 t ha^–1) and from the object 5., on which mechanical treatment was used to the seeding, and after the ultimate formation of furrows before seeding of potato plants, Avatar herbicide 293 was applied in a dose of 1.5 dm³ ha^–1 (total yield amounted to, on average, 40.6 t ha^–1). Potato cultivars cultivated in the experiment and meteorological conditions during the conducted tests also had a significant impact on the size of the total yield. Owacja noted the highest yields (an average of 41.4 t ha^–1). The largest total yield was collected in 2016 (an average of 42.8 t ha^–1). A significant influence of the experiment factors on the structure of large tuber yields was also found.