International Heart Journal
Online ISSN : 1349-3299
Print ISSN : 1349-2365
ISSN-L : 1349-2365
Clinical Studies
A New Criteria Differentiating Type 2 and 3 Brugada Patterns From Ordinary Incomplete Right Bundle Branch Block
Kimie Ohkubo, Ichiro Watanabe, Yasuo Okumura, Sonoko Ashino, Masayoshi Kofune, Koichi Nagashima, Toshiko Nakai, Satoshi Kunimoto, Yuji Kasamaki, Atsushi Hirayama
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Keywords: Brugada syndrome, Right bundle branch block, Antiarrhythmic drug test, QRS angle
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2011 Volume 52 Issue 3 Pages 159-163

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Abstract
The type 1 (coved) ECG pattern is diagnostic for Brugada syndrome; types 2 and 3 require antiarrhythmic drug challenge to confirm its presence. We evaluated a 12-lead ECG-based criterion to differentiate between ordinary incomplete right bundle branch block (iRBBB) and true type 2 and 3 patterns that evolve toward type 1 during drug challenge. The subjects were 22 patients (21 men, 1 woman; mean age, 46.8 ± 13.2 years) referred for drug challenge (1 mg/kg pilsicainide, iv). In magnified ECG lead V1 and/or V2 with an iRBBB pattern, the baseline angle defined as the cross section of the upslope of the r’ wave with the downslope of the r’ wave was measured and compared between patients responding negatively versus positively to drug challenge, and was found to be significantly smaller in patients responding negatively (20.9 ± 12.9°, n = 6, versus 38.7 ± 16.5°, n = 13; P = 0.009). This ECG-based method successfully discriminates between the ordinary iRBBB pattern and drug-induced evolution toward a type 1 Brugada ECG.
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© 2011 by the International Heart Journal Association
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