Lymphoid Tissue Damage in HIV-1 Infection Depletes Naïve T Cells and Limits T Cell Reconstitution after Antiretroviral Therapy
Figure 7
The extent of restoration of naïve T cells after HAART is not associated with viral load or immune activation.
A. Viral load before and after HAART in patients receiving HAART at different stages of infection, showing the inhibition of viral replication is similar for patients at different stage of infection. B. Quantification of the number of Ki67+ cells before and after HAART in patients receiving HAART at different stages of infection, showing the inhibition of immune activation by HAART is similar for patients at different stage of infection (ns, not significant). C, E. Association between the viral load and number of naïve T cells and association between viral load and the number of apoptotic naïve T cells after HAART are not significant. D, F. Association between the number of Ki67+ cells and naïve T cells and association between the number of Ki67+ cells and the number of apoptotic naïve T cells after HAART are not significant.
doi: https://doi.org/10.1371/journal.ppat.1002437.g007