CD39/Adenosine Pathway Is Involved in AIDS Progression
Figure 4
CD39 blocking mAb reverses the suppressive effect of Treg on the cytokine production of Gag-stimulated CD8+ T cells.
Pooled data showing the percentage of CD8+ T cells from c-ART− HIV-1-positive patients (n = 5) producing cytokines (IL2/IFN-g/TNF-a) after overnight stimulation with Gag peptides. CD8+ T cells were cultured in the presence or not of Treg (ratio ¼) and in the presence or not of antiCD39 Mab or isotype control (see M&M). Histograms represent means +/− SD. Statistical differences were assessed by a paired t-test, * P<0.05.
doi: https://doi.org/10.1371/journal.ppat.1002110.g004