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Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G₂/M cell cycle arrest

Fig 13

Signalling model for reduction of G₂/M arrest in A549^rCDDP²⁰⁰⁰ cells.

Preliminary signaling model to explain the lack of a G₂/M arrest in resistant cells indicating significant protein changes after treatment comparing a) A549 and b) A549^rCDDP²⁰⁰⁰ cells based on mRNA data (red arrows) or protein data (green arrows).

doi: https://doi.org/10.1371/journal.pone.0181081.g013