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Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G₂/M cell cycle arrest

Fig 6

p53 mRNA and protein analysis.

Analysis of p53 in a) RT-PCR (n = 3) and b) Western Blot (n = 3) as fold change relative to untreated control in A549 and A549^rCDDP²⁰⁰⁰ cells, presented as mean ± SEM with c) one representative western blot showing A549 untreated, A549 treated with 11 μM cisplatin, A549^rCDDP²⁰⁰⁰ untreated, A549^rCDDP²⁰⁰⁰ treated with 11 μM cisplatin and A549^rCDDP²⁰⁰⁰ treated with 34 μM cisplatin.

doi: https://doi.org/10.1371/journal.pone.0181081.g006