HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation
Fig 4
Activated HIV+ splenocytes fail to produce IL-4 and IL-10: Total splenocytes were stimulated with PHA for 2 days and culture supernatants were analyzed for IL-1ß, IL-6, Il-4 and IL-10 using enhanced sensitivity BD CBA flex set assay.
Horizontal bars represent mean and error bars show SEM. HIV-ITP- n = 4, HIV-ITP+ n = 3, HIV+ITP- n = 4 and HIV+ITP+ n = 5. Statistics were obtained using the non parametric Mann-Whitney test *p<0.05, **p<0.005, ***p<0.001.
doi: https://doi.org/10.1371/journal.pone.0140978.g004