Regulatory Network Structure as a Dominant Determinant of Transcription Factor Evolutionary Rate
Figure 4
Targets of fast evolving TFs have larger expression changes through evolution.
The targets of the 25% fastest evolving TFs, on the right, have on average larger absolute fold changes in expression between S. cerevisiae and S. paradoxus than targets of other TFs, on the left, as determined by RNA-seq. Numbers above the bars represent the number of TFs in the bin.
doi: https://doi.org/10.1371/journal.pcbi.1002734.g004