A Covering Method for Detecting Genetic Associations between Rare Variants and Common Phenotypes
Figure 2
Power of RV analyses, tested over different values of penetrance , PAR
, and
individuals (cases+controls).
For each choice of parameters, test cases were simulated. Each test-case was analyzed using
methods, and the
-value computed using
permutations of cases and controls. The score is considered significant only if it is higher than all permuted values. The power of the test is the fraction of test-cases that had a significant score. RareCover dominates the other methods implying greater power over all choice of parameters. For all methods, power increases with an increase in
, or sample size.
doi: https://doi.org/10.1371/journal.pcbi.1000954.g002