Successful outcome after a single endoscopic fecal microbiota transplantation          in a Shiba dog with non-responsive enteropathy during the treatment with          chlorambucil

Koji SUGITA; Ayaka SHIMA; Kaho TAKAHASHI; Yasuyoshi MATSUDA; Masaki MIYAJIMA; Marin HIROKAWA; Hirotaka KONDO; Junpei KIMURA; Genki ISHIHARA; Keitaro OHMORI

doi:10.1292/jvms.21-0063

Internal Medicine

Successful outcome after a single endoscopic fecal microbiota transplantation in a Shiba dog with non-responsive enteropathy during the treatment with chlorambucil

Koji SUGITA, Ayaka SHIMA, Kaho TAKAHASHI, Yasuyoshi MATSUDA, Masaki MIYAJIMA, Marin HIROKAWA, Hirotaka KONDO, Junpei KIMURA, Genki ISHIHARA, Keitaro OHMORI

Author information

Koji SUGITA
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan
Sugita Animal Hospital, 3-55-10 Shinshiraoka, Shiraoka, Saitama 349-0212, Japan
Ayaka SHIMA
Anicom Specialty Medical Institute Inc., 8-17-1 Nishi-shinjuku, Shinjuku, Tokyo 160-0023, Japan
Kaho TAKAHASHI
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan
Yasuyoshi MATSUDA
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan
Masaki MIYAJIMA
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan
Marin HIROKAWA
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan
Hirotaka KONDO
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-08510, Japan
Junpei KIMURA
College of Veterinary Medicine and Research Institute for Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
Genki ISHIHARA
Anicom Specialty Medical Institute Inc., 8-17-1 Nishi-shinjuku, Shinjuku, Tokyo 160-0023, Japan
Keitaro OHMORI
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan

Keywords: dysbiosis, fecal microbiota transplantation, hypoalbuminemia, non-responsive enteropathy, Shiba dog

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Supplementary material

2021 Volume 83 Issue 6 Pages 984-989

DOI https://doi.org/10.1292/jvms.21-0063

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Abstract

A 7-year 6-month-old, castrated male Shiba dog presented with a 1-month history of lethargy, anorexia, vomiting, and frequent watery diarrhea. Weight loss, hypoalbuminemia, anemia, and leukocytosis were detected at the first visit. The dog was diagnosed with non-responsive enteropathy (NRE) based on clinical and histopathological examinations. Since the dog did not respond to the immunosuppressive drugs, fecal microbiota transplantation (FMT) was performed during the treatment with chlorambucil. A single endoscopic FMT into the cecum and colon drastically recovered clinical signs and clinicopathological abnormalities and corrected dysbiosis in the dog. No recurrence or adverse events were observed. The present case report suggests that FMT, possibly together with chlorambucil, might be a treatment option for NRE in Shiba dogs that have poorer prognosis compared with other dog breeds.

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