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ResearchIn-Press PreviewInfectious diseasePulmonology Open Access | 10.1172/JCI180986
1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
Find articles by Zhang, Y. in: JCI | PubMed | Google Scholar |
1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
Find articles by Wang, Y. in: JCI | PubMed | Google Scholar
1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
4Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, United States of America
5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States of America
6Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
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Published September 10, 2024 - More info
A leading cause of mortality after influenza infection is the development of a secondary bacterial pneumonia. In the absence of a bacterial superinfection, prescribing antibacterial therapies is not indicated but has become a common clinical practice for those presenting with a respiratory viral illness. In a murine model, we found that antibiotic use during influenza infection impaired the lung innate immunologic defenses toward a secondary challenge with methicillin-resistant Staphylococcus aureus (MRSA). Antibiotics augment lung eosinophils, which have inhibitory effects on macrophage function through the release of major basic protein. Moreover, we demonstrated antibiotic treatment during influenza infection causes a fungal dysbiosis that drive lung eosinophilia and impair MRSA clearance. Finally, we evaluated three cohorts of hospitalized patients and found eosinophils positively correlated with antibiotic use, systemic inflammation, and worsened outcomes. Altogether, our work demonstrates a detrimental effect of antibiotic treatment during influenza infection that has harmful immunologic consequences via recruitment of eosinophils to the lungs thereby increasing the risk of developing a secondary bacterial infection.